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首页> 外文期刊>Life sciences >Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.
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Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.

机译：全身服用辣椒碱可防止在豚鼠支气管中辣椒素引起的功能性脱敏和P物质样免疫反应性（SP-LI）的丧失。

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摘要

In this study, we investigated whether the systemically administered capsazepine can prevent the capsaicin-induced desensitization ex vivo in guinea-pig bronchi. Pretreatment with capsaicin (2.5, 5 and 10 mg/kg, s.c.) induced the functional desensitization and the loss of substance P-like immunoreactivity (SP-LI) with a similar potency (ED50: 3.31 +/- 0.57 and 4.81 +/- 0.89 mg/kg, respectively) in isolated guinea-pig bronchi. Capsazepine (30 mg/kg, s.c.) co-administered with capsaicin (5 mg/kg, s.c.) prevented the capsaicin (5 mg/kg, s.c.)-induced functional desensitization and loss of SP-LI. These results suggest that capsazepine can antagonize systemically the desensitizing action of capsaicin at the level of receptor, preventing the loss of SP-LI and the establishment of functional desensitization in guinea-pig bronchi.
机译：在这项研究中，我们调查了全身注射的辣椒碱是否可以预防辣椒素引起的豚鼠支气管离体脱敏。用辣椒素（2.5、5和10 mg / kg，皮下注射）进行预处理可引起功能性脱敏和P样物质免疫反应性（SP-LI）丧失，效能相似（ED50：3.31 +/- 0.57和4.81 +/-在分离的豚鼠支气管中分别为0.89 mg / kg。辣椒素（30 mg / kg，s.c.）与辣椒素（5 mg / kg，s.c.）并用可预防辣椒素（5 mg / kg，s.c.）引起的功能性脱敏和SP-LI的丧失。这些结果表明，辣椒素可以在受体水平上拮抗辣椒素的脱敏作用，防止SP-LI的损失并在豚鼠支气管中建立功能性脱敏。

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