• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >THE RATE OF TRANSBILAYER MOVEMENT OF ERYTHROCYTE MEMBRANE CHOLESTEROL IS CORRELATED WITH SODIUM-LITHIUM COUNTERTRANSPORT
【24h】

THE RATE OF TRANSBILAYER MOVEMENT OF ERYTHROCYTE MEMBRANE CHOLESTEROL IS CORRELATED WITH SODIUM-LITHIUM COUNTERTRANSPORT

机译：红细胞膜胆固醇的跨膜运动速率与钠锂逆向运动相关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hypertension is associated with some abnormalities in cell membrane structure, including an impaired distribution of cholesterol into the monolayers of erythrocyte membrane. Transbilayer movement of membrane cholesterol modulates the formation of these structural cholesterol domains. We tested whether the rate of cholesterol movement may influence on the erythrocyte Na+-Li+ countertransport, that is a marker of human essential hypertension. In single regression analysis, the half-time for the decrease in specific radioactivity of cholestenone (inverse of membrane cholesterol transbilayer movement) was negatively related to the erythrocyte cation flux mediated by Na+-Li+ countertransport (r=-0.8983, P<0.0001 for control subjects; r=-0.8191, P<0.005 for normocholesterolaemic hypertensive patients; r=-0.7664, P<0.005 for hypercholesterolaemic hypertensive patients). These data suggest that changes in the transbilayer movement of membrane cholesterol interfere with the main cation transport system which is implicated in the pathophysiology of essential hypertension. This also provides a new link between kinetic cholesterol pools and cell membrane functions. [References: 14]
机译：高血压与细胞膜结构异常有关，包括胆固醇进入红细胞膜单层的分布受损。膜胆固醇的跨双层运动调节这些结构胆固醇结构域的形成。我们测试了胆固醇运动的速率是否会影响红细胞Na + -Li +逆向转运，这是人类原发性高血压的标志。在单次回归分析中，胆甾烯酮比放射性降低的一半时间（膜胆固醇跨双层运动的逆过程）与Na + -Li +逆转运介导的红细胞阳离子通量呈负相关（r = -0.8983，P <0.0001作为对照）受试者;对于正常胆固醇血症的高血压患者，r = -0.8191，P <0.005;对于高胆固醇血症的高血压患者，r = -0.7664，P <0.005）。这些数据表明，膜胆固醇的跨双层运动变化会干扰主要的阳离子转运系统，这与原发性高血压的病理生理学有关。这也提供了动态胆固醇池与细胞膜功能之间的新联系。 [参考：14]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号