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首页> 外文期刊>Life sciences >INCREASED LYMPHOCYTIC NA+/H+ EXCHANGE ACTIVITY AFTER HEMODIALYSIS - EVIDENCE FOR AN ENDOGENOUS INHIBITOR OF NA+/H+ EXCHANGE IN PATIENTS WITH END-STAGE RENAL FAILURE
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INCREASED LYMPHOCYTIC NA+/H+ EXCHANGE ACTIVITY AFTER HEMODIALYSIS - EVIDENCE FOR AN ENDOGENOUS INHIBITOR OF NA+/H+ EXCHANGE IN PATIENTS WITH END-STAGE RENAL FAILURE

机译：血液透析后淋巴细胞的NA + / H +交换活性增加-终末期肾功能衰竭患者内源性NA + / H +交换抑制剂的证据

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The Na+/H+ exchange antiport activity was measured in lymphocytes from 16 patients with end-stage renal failure pre- and postdialysis. In addition the effect of the patients' plasma on lymphocytes from healthy subjects was tested. Resting pH (pH(i)) was not significantly different in lymphocytes pre- and postdialysis. On the other hand, the Na+/H+ exchange activity was significantly lower in lymphocytes before hemodialysis (6.22 +/- 0.73 x 10(-3) pH(i)/s) than after hemodialysis (9.32 +/- 1.58 x 10(-3) pH(i)/s; n=16; p<0.05). The buffer capacity was not significantly different before and after hemodialysis. The incubation of lymphocytes from healthy control subjects with plasma from patients with end-stage chronic renal failure significantly reduced the lymphocytic Na+/H+ exchange activity. The addition of ultrafiltrate also significantly reduced the Na+/H+ exchange activity in lymphocytes from healthy control subjects. The study indicates the existence of an endogenous inhibitor of the Na+/H+ exchange that is accumulated in plasma from patients with end-stage chronic renal failure. [References: 17]
机译：在16例患有终末期肾衰竭的透析前后患者的淋巴细胞中测量了Na + / H +交换反转运活性。另外，测试了患者血浆对健康受试者淋巴细胞的影响。透析前后淋巴细胞的静息pH（pH（i））均无显着差异。另一方面，血液透析前淋巴细胞的Na + / H +交换活性显着低于血液透析后（6.22 +/- 0.73 x 10（-3）pH（i）/ s）（9.32 +/- 1.58 x 10（-） 3）pH（i）/ s; n ＝ 16; p ＜0.05）。血液透析前后缓冲液容量无明显差异。健康对照对象的淋巴细胞与晚期慢性肾功能衰竭患者的血浆孵育后，可显着降低淋巴细胞的Na + / H +交换活性。超滤液的添加也显着降低了健康对照对象淋巴细胞中的Na + / H +交换活性。该研究表明存在一种内源性Na + / H +交换抑制剂，该抑制剂在晚期慢性肾功能衰竭患者的血浆中积累。 [参考：17]

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