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首页> 外文期刊>Life sciences >EFFECT OF MOTILIN, SOMATOSTATIN AND BOMBESIN ON GASTRODUODENAL MYOELECTRIC ACTIVITY IN SHEEP
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EFFECT OF MOTILIN, SOMATOSTATIN AND BOMBESIN ON GASTRODUODENAL MYOELECTRIC ACTIVITY IN SHEEP

机译：胃泌素，生长抑素和弹力蛋白对绵羊胃十二指肠肌电活动的影响

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The effects of motilin, erythromycin, somatostatin and bombesin on antroduodenal myoelectric activity were investigated in conscious sheep. Myoelectric recordings were obtained from electrodes chronically implanted on the antrum and the duodenal bulb. Peptides or erythromycin were infused intravenously (i.v.) during 5 min. Antagonists were injected i.v. as a bolus. Neither motilin (2.5-80 ng/kg/min) nor erythromycin (2-16 mu g/kg/min) modified the antroduodenal myoelectric activity, although a single bolus of these compounds (250 ng/kg and 50 mu g/kg respectively) increased the antral activity. Somatostatin at 5 ng/kg/min induced a decrease in the myoelectric activity of antrum and duodenum. However, doses of 10 to 40 ng/kg/min evoked a duodenal phase III-like activity with a subsequent quiescence period and a concomitant inhibition of the antral activity. These effects were reproduced by bombesin (2.5 to 40 ng/kg/min). Furthermore, an initial increase in the myoelectric activity and in the frequency of slow waves were recorded in the antrum when the highest doses were used. On the other hand, atropine (0.2 mg/kg) or hexamethonium (2 mg/kg) caused a long-lasting inhibition of antroduodenal myoelectric activity. These cholinergic antagonists abolished the effects induced by somatostatin (20 ng/kg/min) but not those evoked by bombesin (10 ng/kg/min). These results suggest that somatostatin and bombesin but not motilin are putative modulators of the migrating myoelectric complex (MMC) in sheep. Moreover, a cholinergic neural pathway is involved in the somatostatin but not in the bombesin-induced effects. [References: 47]
机译：在有意识的绵羊中研究了胃动素，红霉素，生长抑素和蛙皮素对十二指肠肌电活动的影响。肌电记录是从长期植入窦腔和十二指肠球的电极获得的。在5分钟内静脉内（i.v.）输注肽或红霉素。静脉内注射拮抗剂。作为推注。胃动素（2.5-80 ng / kg / min）或红霉素（2-16μg/ kg / min）均未改变十二指肠肌电活动，尽管这些化合物一次大剂量（分别为250 ng / kg和50μg/ kg） ）增加了肛门活动。以5 ng / kg / min的生长抑素诱导胃窦和十二指肠的肌电活动降低。但是，剂量为10到40 ng / kg / min引起十二指肠III期样活性，随后处于静止期，并伴随着对肛门活性的抑制。这些影响通过蛙心素（2.5至40 ng / kg / min）再现。此外，当使用最高剂量时，在胃窦中记录了肌电活动和慢波频率的初始增加。另一方面，阿托品（0.2 mg / kg）或六甲铵（2 mg / kg）导致对十二指肠肌电活动的长期抑制。这些胆碱能拮抗剂消除了生长抑素（20 ng / kg / min）诱导的作用，但没有消除蛙皮素（10 ng / kg / min）引起的作用。这些结果表明，生长抑素和蛙皮素而不是胃动素是绵羊中迁移的肌电复合物（MMC）的假定调节剂。此外，胆碱能神经通路与生长抑素有关，但与蛙皮素诱导的作用无关。 [参考：47]

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