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首页> 外文期刊>Life sciences >ALPHA-TOCOPHEROL PRETREATMENT PROTECTS THE ENDOCRINE FUNCTION OF GRAFTS AGAINST ISCHEMIC DAMAGE DURING HETEROTOPIC PANCREATIC TRANSPLANTATION
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ALPHA-TOCOPHEROL PRETREATMENT PROTECTS THE ENDOCRINE FUNCTION OF GRAFTS AGAINST ISCHEMIC DAMAGE DURING HETEROTOPIC PANCREATIC TRANSPLANTATION

机译：α-间苯二酚的预处理可保护移植物在异种胰胰腺移植过程中对缺血性损伤的内分泌功能

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Post-ischemic injury is one of the most important problems affecting successful organ procurement and transplantation. The present study was performed to determine whether alpha-tocopherol can protect the endocrine function of pancreatic grafts against ischemia-reperfusion injury during rat heterotopic pancreatic transplantation. Rats with streptozotocin-induced hyperglycemia were used as recipients. The donor pancreas was removed and subjected to warm ischemia at 37 degrees C for 30, 60, 90 and 120 min, and then transplanted into a recipient. A 30-min period of warm ischemia did not impair the endocrine function of the pancreatic grafts, which was assessed by measuring the blood glucose levels and glucose decay constants (K), and a 60-min period of warm ischemia was considered to be the critical period for reversible tissue damage. Pretreatment with alpha-tocopherol (20 mg/kg/day, i.v.) for seven days before graftectomy significantly decreased blood glucose levels to less than 200 mg/dl and significantly increased K values in the recipient rats after transplantation when compared with placebo pretreatment. These results suggest that alpha-tocopherol pretreatment can protect the endocrine function of pancreatic grafts against injury due to warm ischemia followed by reperfusion. [References: 15]
机译：缺血后损伤是影响器官成功获得和移植的最重要问题之一。进行本研究是为了确定在大鼠异位胰腺移植过程中，α-生育酚是否能保护胰腺移植物的内分泌功能免受缺血再灌注损伤。具有链脲佐菌素诱导的高血糖的大鼠用作受体。取出供体胰腺并在37℃下进行30、60、90和120分钟的热缺血，然后移植到受体中。 30分钟的热缺血不会损害胰腺移植物的内分泌功能，这是通过测量血糖水平和葡萄糖衰减常数（K）来评估的，而60分钟的热缺血被认为是胰腺的内分泌功能。可逆组织损伤的关键时期。与安慰剂预处理相比，移植后7天进行α-生育酚（20 mg / kg /天，静脉内）预处理可显着降低血糖水平，使其低于200 mg / dl，并显着提高移植后受体大鼠的K值。这些结果表明，α-生育酚预处理可以保护胰腺移植物的内分泌功能免受温暖缺血再灌注引起的损伤。 [参考：15]

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