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首页> 外文期刊>Life sciences >Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress.
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Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress.

机译：暴露于束缚和手术压力下的高催乳素大鼠的血糖和催乳激素。

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The effects of chronic hyperprolactinemia on plasma prolactin (PRL) and glucose were investigated in male rats submitted to two different types of stress: restraint (60 min in a plastic tube) or surgery (laparotomy under ether anesthesia). Hyperprolactinemia was induced by grafting one homologous pituitary gland under the kidney capsule. Restraint stress induced a marked increase of plasma PRL of control rats with a peak at 15 min (increase of 403%), but did not change the PRL levels of hyperprolactinemic rats. Plasma glucose levels of both groups were elevated by restraint stress at 5 min (control, 26%; grafted, 63%), and remained above basal levels during the whole experimental period. However, at 15 min the hyperglycemic response of the grafted rats was higher than that of control rats (p<0.05). Surgical stress induced a 204% increase of plasma PRL at 5 min in the control group, but failed to induce alterations of PRL in the hyperprolactinemic group. Plasma glucose was remarkably elevated at 15 min both in control (138%) and grafted (124%) rats after surgery, producing a hyperglycemic response much more intense than that induced by restraint. Grafted rats presented hyperglycemia during all the experimental period, whereas control rats showed glycemia similar to basal levels by the end of the experiment. In conclusion, different responses are induced depending on the type of stress: more intense PRL secretion is induced by restraint and higher hyperglycemia by surgery. Chronic hyperprolactinemia induced a higher (restraint) or longer lasting (surgery) hyperglycemic response in the rat, adding new evidence for a diabetogenic effect of PRL.
机译：在遭受两种不同类型压力的雄性大鼠中研究了慢性高泌乳素血症对血浆催乳素（PRL）和葡萄糖的影响：束缚（在塑料管中60分钟）或手术（在乙醚麻醉下开腹）。高泌乳素血症是通过在肾囊下移植一个同源的垂体腺引起的。束缚应激导致对照组大鼠血浆PRL显着增加，在15分钟达到峰值（增加403％），但并未改变高催乳素大鼠的PRL水平。两组的血浆葡萄糖水平在5分钟时因束缚压力而升高（对照组，为26％;移植为63％），并且在整个实验期间均保持高于基础水平。然而，在第15分钟时，移植大鼠的高血糖反应高于对照组（p <0.05）。手术应力在对照组中在5分钟时诱导血浆PRL增加204％，但在高催乳激素组中未引起PRL改变。对照组（138％）和移植后（124％）大鼠的血浆葡萄糖在手术后15分钟均显着升高，产生的高血糖反应比约束引起的反应强烈得多。嫁接的大鼠在整个实验期间均表现出高血糖，而对照大鼠在实验结束时表现出与基础水平相似的血糖。总之，根据压力的类型会引起不同的反应：束缚会导致PRL分泌更旺盛，而手术会引起更高的高血糖。慢性高泌乳素血症在大鼠中引起更高的（约束）或更长的（手术）高血糖反应，为PRL的致糖尿病作用提供了新的证据。

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