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首页> 外文期刊>Life sciences >THE ROLE OF VASOPRESSIN, SOMATOSTATIN AND GABA IN FEBRILE CONCLUSION IN RAT PUPS
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THE ROLE OF VASOPRESSIN, SOMATOSTATIN AND GABA IN FEBRILE CONCLUSION IN RAT PUPS

机译：加压素，生长抑素和GABA在大鼠小结结论中的作用

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In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR). Male Wistar rats at 16 days of age irradiated with UR developed generalized convulsions after 4.9 +/- 0.5 min irradiation. Six rats were killed by microwave irradiation 3 min after UR irradiation prior to convulsion development, and 29 rats were killed either 0 min, 2 h, 6 h, 24 h or 48 h after febrile convulsions. Non-irradiated rats served as controls. The rat brain was dissected into 4 regions; amygdala, hypothalamus, cortex and hippocampus, and subjected to radioimmunoassays. IR-AVP levels in hypothalamus were increased 3 min after UR and decreased at 2 h and 6 h after the convulsions. IR-SRIF levels were increased in cortex and hippocampus at 3 min after UR and 0 min after the convulsions. The GABA content increased in all regions tested at 2 h and 6 h after the convulsions. These results suggest that AVP, SRIF and GABA may be involved in the pathogenesis of febrile convulsions in different ways. [References: 33]
机译：为了进一步阐明神经肽和GABA在高热惊厥发病中的可能作用，我们研究了免疫反应性精氨酸加压素（IR-AVP），IR-生长抑素（IR-SRIF）和γ-氨基丁酸（GABA）的变化。超红光（UR）引起的高热惊厥后的大鼠大脑。用UR辐照的16天大的Wistar雄性大鼠在辐照4.9 +/- 0.5分钟后出现全身性惊厥。在惊厥发生之前，在UR照射后3分钟用微波照射杀死6只大鼠，在高热惊厥后0分钟，2 h，6 h，24 h或48 h处死29只大鼠。未辐照的大鼠作为对照。将大鼠大脑分成4个区域。杏仁核，下丘脑，皮层和海马，并接受放射免疫分析。下丘脑的IR-AVP水平在UR后3分钟升高，在惊厥后2小时和6小时降低。 UR后3分钟和惊厥后0分钟，皮质和海马的IR-SRIF水平升高。惊厥后2小时和6小时，所有测试区域的GABA含量均增加。这些结果表明，AVP，SRIF和GABA可能以不同的方式参与高热惊厥的发病机理。 [参考：33]

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