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Betula platyphylla attenuated mast cell-mediated allergic inflammation in vivo and in vitro

机译：白桦在体内和体外减轻肥大细胞介导的变态反应性炎症

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Aims Betula platyphylla (B. platyphylla) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of B. platyphylla is not completely understood. The aim of the present study is to elucidate whether and how B. platyphylla modulates the mast cell-mediated allergy inflammation in vitro and in vivo. Main methods We investigated to ascertain the pharmacological effects of B. platyphylla on both compound 48/80 or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of B. platyphylla, we evaluated the effects of B. platyphylla on the release of histamine in compound 48/80-induced rat peritoneal mast cells (RPMCs), production of inflammatory mediators and activation of nuclear factor-κB (NF-κB) and caspase-1 in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Key findings The finding of this study demonstrated that B. platyphylla reduced compound 48/80 or histamine-induced scratching behaviors and DNFB-induced atopic dermatitis in mice. Additionally, B. platyphylla inhibited the release of histamine in RPMC and production of inflammatory cytokines as well as the activation of NF-κB and caspase-1 in stimulated HMC-1. Significance Collectively, the findings of this study provide us with novel insights into the pharmacological actions of B. platyphylla as a potential molecule for use in the treatment of allergic inflammatory diseases.
机译：目的白桦（B. platyphylla）在韩国传统上用于治疗炎性疾病。但是，尚不完全了解导致白僵菌抗炎作用的确切机制。本研究的目的是阐明白桦芽孢杆菌是否以及如何在体外和体内调节肥大细胞介导的变态反应性炎症。主要方法我们调查以确定白桦双歧杆菌对化合物48/80或组胺诱导的scratch抓行为和2,4-二硝基氯苯（DNCB）诱导的特应性皮炎的药理作用。此外，为了找到可能的白桦芽孢杆菌抗炎作用的解释，我们评估了白桦芽胞杆菌对化合物48/80诱导的大鼠腹膜肥大细胞（RPMC）中组胺释放，炎症介质产生的影响。佛波醇12-肉豆蔻酸酯13-乙酸酯加上钙离子载体A23187（PMACI）刺激的人类肥大细胞（HMC-1）中核因子-κB（NF-κB）和caspase-1的活化。关键发现这项研究的发现表明，白叶双歧杆菌减少了化合物48/80或组胺诱导的scratch抓行为以及DNFB诱导的特应性皮炎。此外，白桦芽胞杆菌抑制了RPMC中组胺的释放和炎性细胞因子的产生以及刺激的HMC-1中NF-κB和caspase-1的活化。意义集体而言，这项研究的发现为我们揭示了白桦芽孢杆菌作为潜在的分子用于治疗过敏性炎症疾病的药理作用的新颖见解。

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