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首页> 外文期刊>Life sciences >17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized adult and middle-aged rats
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17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized adult and middle-aged rats

机译：17-β雌二醇对去卵巢成年和中年大鼠脑和血液中乙酰胆碱酯酶活性和脂质过氧化的影响

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Aims: To investigate the 17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized rats of different ages. Main methods: Animals were randomly assigned into three experimental groups of each age (n = 6). Control groups consisted of adult (sham-A) and middle-aged (sham-MA) female rats, ovariectomized adult (OVX-A) and middle-aged (OVX-MA) rats without estrogen therapy reposition, and ovariectomized adult (OVX + E2-A) and middle-aged (OVX + E2-MA) rats treated with 17-β estradiol for 30 days. After this period, AChE activity and lipid peroxidation were measured in the brain and blood. Key findings: The AChE activity increased (p < 0.05) in striatum (ST) in OVX-A, OVX + E2-A and OVX-MA, and hippocampus (HP) in OVX-MA. The enzyme activity decreased (p < 0.05) in ST of OVX + E2-MA, and cerebral cortex (CC) in OVX + E2-A, OVX-MA and OVX + E2-MA. Blood AChE activity increased (p < 0.05) in OVX + E2-A and decreased (p < 0.05) in OVX-MA. Lymphocyte AChE activity increased (p < 0.05) in OVX-A and OVX + E2-A and decreased (p < 0.05) in OVX-MA. Lipid peroxidation increased (p < 0.05) in ST of OVX-A, CC of OVX-A and OVX-MA, HP of OVX-A, and cerebellum (CE) of OVX-A, OVX-MA, and OVX + E2-MA. Lipid peroxidation decreased (p < 0.05) in ST, CC and CE of OVX + E2-A, and ST and HP of OVX + E2-MA. Similar values of lipid peroxidation to control groups were found in ST and HP of OVX-MA, HP of OVX + E2-A and CC of OVX + E2-MA. Significance: 17-β estradiol is able to modulate the AChE activity and non-neuronal cholinergic response as well as to reduce lipid peroxidation. Its response is dependent on the age and brain structure analyzed.
机译：目的：研究17-β雌二醇对不同年龄卵巢切除的大鼠脑和血液中乙酰胆碱酯酶活性和脂质过氧化的影响。主要方法：将动物随机分为每个年龄段的三个实验组（n = 6）。对照组由成年（sham-A）和中年（sham-MA）雌性大鼠，无雌激素治疗复位的去卵巢成年大鼠（OVX-A）和中年（OVX-MA）大鼠以及去卵巢成年大鼠（OVX + E2-A）和中年（OVX + E2-MA）大鼠用17-β雌二醇治疗30天。在这段时间之后，测量大脑和血液中的AChE活性和脂质过氧化。主要发现：OVX-A，OVX + E2-A和OVX-MA的纹状体（ST）中的AChE活性增加，OVX-MA的海马（HP）的AChE活性增加。 OVX + E2-MA的ST中的酶活性降低（p <0.05），OVX + E2-A，OVX-MA和OVX + E2-MA的大脑皮层（CC）。 OVX + E2-A的血液AChE活性增加（p <0.05），而OVX-MA的血液AChE活性降低（p <0.05）。淋巴细胞AChE活性在OVX-A和OVX + E2-A中增加（p <0.05），而在OVX-MA中降低（p <0.05）。 OVX-A的ST，OVX-A和OVX-MA的CC，OVX-A的HP和OVX-A，OVX-MA和OVX + E2-的小脑（CE）的脂质过氧化增加（p <0.05）嘛。 OVX + E2-A的ST，CC和CE以及OVX + E2-MA的ST和HP的脂质过氧化减少（p <0.05）。在OVX-MA的ST和HP，OVX + E2-A的HP和OVX + E2-MA的CC中，脂质过氧化的值与对照组相似。意义：17-β雌二醇能够调节AChE活性和非神经元胆碱能反应，并减少脂质过氧化。它的反应取决于所分析的年龄和大脑结构。

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