• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model
【24h】

Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model

机译：橙皮苷和鞣花酸在小鼠模型中对腹泻性嗜水气单胞菌的抗菌和免疫调节活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims The present study is designed to evaluate the in vitro and in vivo bactericidal and immunomodulating activities of hesperidin (HES) and ellagic acid (EA) against Aeromonas hydrophila. A hydrophila, an uncommon human pathogen, can cause invasive infections in immunocompromised individuals and common clinical presentations in acute gastrointestinal illness, soft-tissue infections and sepsis. The antimicrobial activities of medicinal plants against A. hydrophila have received only cursory attention. Methods We examined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values in vitro. Moreover, the effects of HES and EA against bacterial colonization were studied in vivo. Also, humoral immune response was tested against A. hydrophila-LPS or A. hydrophila-ECP antigen preparations and the intestinal histopathological alterations were studied. Results Data revealed that the treatments with HES and EA each had antimicrobial activities against A. hydrophila. Both HES and EA treatments significantly increased anti-LPS IgM levels and reduced anti-LPS and anti-ECP IgA levels to their normal values in comparison to the infected group, which recorded significantly elevated levels two week post-infection. In conclusion, the present data suggest that HES and EA have antimicrobial and immunomodulating activities against murine A. hydrophila infections. Significant These data warrant clinical studies to delineate HES and EA roles in human infectious diseases.
机译：目的本研究旨在评估橙皮苷（HES）和鞣花酸（EA）对嗜水气单胞菌的体外和体内杀菌和免疫调节活性。嗜水菌是一种罕见的人类病原体，可导致免疫力低下的人受到侵袭性感染，并在急性胃肠道疾病，软组织感染和败血症中引起常见的临床表现。药用植物对亲水曲霉的抗菌活性仅受到粗略的关注。方法我们检查了体外的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）值。此外，在体内研究了HES和EA对细菌定植的影响。此外，还针对体液性链球菌-LPS或体液性链球菌-ECP抗原制剂测试了体液免疫反应，并研究了肠道组织病理学改变。结果数据显示，HES和EA的处理均对亲水曲霉具有抗菌活性。与感染组相比，HES和EA治疗均显着提高了抗LPS IgM水平并将抗LPS和抗ECP IgA水平降低至正常值，感染后两周的水平明显升高。总之，目前的数据表明，HES和EA具有抗鼠亲水链球菌感染的抗菌和免疫调节活性。重要的这些数据值得临床研究来描述HES和EA在人类传染病中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号