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首页> 外文期刊>Life sciences >Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury
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Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury

机译：萘甲地尔，一种α1D/ A-肾上腺素受体拮抗剂对脊髓损伤大鼠膀胱的影响

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Aims Alpha1D-adrenoceptors (α1D-ARs) located in the spinal cord are involved in the control of lower urinary tract function. In order to clarify the effect of α1D-ARs on storage function in the spinal cord, we examined the effect of oral administration and intrathecal injection of the α1D/A-AR antagonist, naftopidil, on bladder activity, as well as the effect of naftopidil on bladder wall histology, in female rats with spinal cord injury (SCI). Main methods Adult female Sprague-Dawley rats with Th9-10 spinal cord transection were used. In SCI rats with or without 5 mg/day of naftopidil for 4 weeks, bladder activity was examined via continuous cystometry. In other SCI rats, bladder activity was examined before and after intrathecal injection of naftopidil. In addition, bladder wall histology was compared between SCI rats with or without oral administration of naftopidil for 4 weeks. Key findings Oral administration of naftopidil decreased the number of non-voiding contractions (NVCs). Intrathecal injection of naftopidil prolonged the interval between voiding contractions, decreased the maximum voiding contraction pressure and the number of NVCs, and increased bladder capacity without affecting the residual urine volume. Oral administration of naftopidil also decreased bladder wall fibrosis. Significance The α1D/A-AR antagonist naftopidil might act on the bladder and spinal cord to improve detrusor hyperreflexia in the storage state in SCI female rats. Naftopidil also suppressed bladder wall fibrosis, suggesting that it may be effective for the treatment of neurogenic lower urinary tract dysfunction after SCI.
机译：目的位于脊髓的Alpha1D肾上腺素能受体（α1D-ARs）参与下尿路功能的控制。为了阐明α1D-ARs对脊髓储存功能的影响，我们研究了口服和鞘内注射α1D/ A-AR拮抗剂那夫托地尔对膀胱活动的影响，以及那夫多地尔的影响。对脊髓损伤（SCI）雌性大鼠膀胱壁组织学的影响主要方法使用成年雌性Sprague-Dawley大鼠进行Th9-10脊髓横断。在有或没有5 mg /天的萘甲地尔连续4周的SCI大鼠中，通过连续膀胱测压法检查膀胱活动。在其他SCI大鼠中，在鞘内注射那夫多地之前和之后检查了膀胱活动。另外，比较了有或没有口服萘甲地尔4周的SCI大鼠之间的膀胱壁组织学。主要研究结果口服萘甲酚可减少非排空性收缩（NVC）的数量。鞘内注射那非地尔可延长排尿收缩之间的间隔，降低最大排尿收缩压力和NVC数量，并增加膀胱容量，而不会影响残余尿量。口服那夫多地尔也可以减少膀胱壁纤维化。意义α1D/ A-AR拮抗剂那夫多地尔可能在SCI雌性大鼠的储存状态下作用于膀胱和脊髓以改善逼尿肌反射亢进。 Naftopidil还可以抑制膀胱壁纤维化，表明它可能对治疗SCI后神经源性下尿路功能障碍有效。

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