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首页> 外文期刊>Life sciences >COCAINE AND BENZOYLECGONINE CONSTRICT CEREBRAL ARTERIES BY DIFFERENT MECHANISMS
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COCAINE AND BENZOYLECGONINE CONSTRICT CEREBRAL ARTERIES BY DIFFERENT MECHANISMS

机译：可卡因和苯甲酰胆碱通过不同机制约束脑动脉

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This study was designed to determine possible mechanisms underlying the vasoconstrictor activity of cocaine and its principal metabolite, benzoylecgonine (BE) in cat isolated cerebral arteries. The arteries constricted significantly in response to single doses of cocaine, BE and norepinephrine (NE; (P < 0.05). After 6-OHDA treatment to remove adrenergic nerve endings, NE-induced constrictions were essentially unchanged from those before treatment. Denervated arteries exposed to cocaine dilated significantly (P < 0.05) but those exposed to BE constricted as much as before denervation. Following exposure to prazosin and yohimbine, arterial constrictions to NE and cocaine were significantly reduced from control (P < 0.05) but the BE-induced constriction was unchanged. Ryanodine eliminated the cocaine-induced contraction (P < 0.05) whereas verapamil eliminated the BE response (P < 0.05). These data suggest that while cocaine's vasoconstrictor action may be significantly mediated through adrenergic transmission, BE may act through a mechanism involving calcium (Ca2+) channels. Cocaine levels peak and decline in the body more rapidly than BE levels which can remain detectable for days. This study suggests there may also be different pharmacological mechanisms as well as temporal differences underlying the vasoreactivity of these two substances. Our findings may have implications for pharmacological management of cocaine-induced toxic vascular events. [References: 35]
机译：本研究旨在确定可卡因及其主要代谢产物苯甲酰芽子碱（BE）在猫分离的脑动脉中的血管收缩活性的潜在机制。对单剂量可卡因，BE和去甲肾上腺素的反应，动脉明显收缩（NE;（P <0.05）。6-OHDA治疗去除肾上腺能神经末梢后，NE引起的收缩与治疗前基本没有变化。可卡因的最大扩张（P <0.05），但是暴露于BE的那些收缩程度与去神经前一样多;暴露于哌唑嗪和育亨宾后，对NE和可卡因的动脉收缩比对照组明显降低（P <0.05），但BE引起的收缩Ryanodine消除了可卡因引起的收缩（P <0.05），而Verapamil消除了BE反应（P <0.05）。这些数据表明，虽然可卡因的血管收缩作用可能是通过肾上腺素的传递来显着介导的，但BE可能通过一种涉及钙（Ca2 +）通道。可卡因水平在人体中的峰值和下降速度要快于BE水平，后者在d没错这项研究表明，这两种物质的血管反应性可能也存在不同的药理机制和时间差异。我们的发现可能对可卡因诱发的毒性血管事件的药理管理有影响。 [参考：35]

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