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首页> 外文期刊>Life sciences >Epithelial cell proliferation and biodistribution of radiolabeled urogastrone in the gastrointestinal mucosa of young and old mice.
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Epithelial cell proliferation and biodistribution of radiolabeled urogastrone in the gastrointestinal mucosa of young and old mice.

机译：幼年和老年小鼠胃肠道粘膜中放射性标记的尿胃泌素的上皮细胞增殖和生物分布。

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摘要

We have evaluated epithelial cell proliferation and biodistribution of radiolabeled recombinant human urogastrone/epidermal growth factor (125I rhUG/EGF) in the gastrointestinal mucosa of young (2+ months) and old (30+ months) mice. Animals were injected intraperitoneally with the metaphase arrest agent vincristine sulfate and intravenously with 125I rhUG/EGF. Animals were killed after two hours. Crypt cell production rate and uptake of radiolabeled urogastrone were measured in the same intestinal tissues. The results demonstrated that older animals had significantly greater crypt cell production rate as compared to young. However, the uptake of 125I rhUG/EGF was not significantly different (except in duodenum, where the uptake of 125I rhUG/EGF was significantly greater in young compared to old animals) between young and old animals. This suggests that increased epithelial cell proliferation in the aging animals is not associated with increased uptake of 125I rhUG/EGF. Thus epidermal growth factor/urogastrone may not be a primary factor for the intestinal kinetic differences which exist between young and old animals.
机译：我们已经评估了年轻（2+个月）和大龄（30+个月）小鼠胃肠道粘膜中放射性标记的重组人尿胃泌素/表皮生长因子（125I rhUG / EGF）的上皮细胞增殖和生物分布。给动物腹膜内注射中期停滞剂硫酸长春新碱，然后静脉内注射125 I rhUG / EGF。两个小时后杀死动物。在相同的肠组织中测量隐窝细胞的产生速率和放射性标记的泌尿激素的摄取。结果表明，与年幼的动物相比，年长的动物的隐窝细胞产生率明显更高。然而，在幼年和老年动物之间，125 I rhUG / EGF的摄取没有显着差异（十二指肠除外，在十二指肠中，幼年动物的125 I rhUG / EGF的摄取显着大于老年动物）。这表明衰老动物中上皮细胞增殖的增加与125 I rhUG / EGF摄取的增加无关。因此，表皮生长因子/泌尿生殖激素可能不是成年和成年动物之间肠道动力学差异的主要因素。

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