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STRAIN-DEPENDENT VARIABILITY IN NITROUS OXIDE WITHDRAWAL SEIZURE FREQUENCY

机译：一氧化二氮抽取麻醉频率的应变相关变异性

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Exposure to nitrous oxide produces handling induced convulsions following withdrawal in mice. Since strain differences in responsiveness to the antinociceptive potency of N2O have been found, we examined whether there were differences in susceptibility to N2O withdrawal seizures. Significant differences were found between mouse strains, varying between 100% and 0% of mice exhibiting withdrawal seizures. There was a lack of correlation between the sensitivity of the mouse strains to N2O-induced analgesia and N2O withdrawal seizures, suggesting different mechanisms of action. [References: 38]
机译：暴露于小鼠体内后，暴露于一氧化二氮会产生诱发的惊厥。由于已发现菌株对N2O的抗伤害感受力的反应存在差异，因此我们检查了对N2O戒断发作的敏感性是否存在差异。发现小鼠品系之间存在显着差异，表现出戒断性癫痫发作的小鼠介于100％和0％之间。小鼠品系对N2O诱导的镇痛的敏感性与N2O戒断癫痫发作之间缺乏相关性，表明了不同的作用机制。 [参考：38]

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