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首页> 外文期刊>Life sciences >Beta3-adrenoceptor mechanisms in guinea-pig taenia caecum.
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Beta3-adrenoceptor mechanisms in guinea-pig taenia caecum.

机译：豚鼠带盲肠的β3-肾上腺素受体机制。

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摘要

Beta-adrenoceptor-mediated relaxation of guinea-pig taenia caecum was investigated by studying the effects of BRL37344, CGP12177 and norepinephrine. These drugs caused graded relaxation of the guinea-pig taenia caecum. The concentration-response curves for these drugs were unaffected by propranolol, atenolol, butoxamine, prazosin, yohimbine and phentolamine. Bupranolol produced shifts of the concentration-response curves for these drugs. Schild regression analyses carried out for bupranolol against BRL37344, CGP12177 and norepinephrine gave pA2 values of 5.79, 5.61 and 5.53, respectively. CGP12177 and norepinephrine significantly increased cyclic AMP levels in this preparation. Bupranolol significantly decreased cyclic AMP levels elicited by CGP12177 and norepinephrine, whereas propranolol produced no effect. These results suggest that the relaxant responses to BRL37344, CGP12177 and norepinephrine in the guinea-pig taenia caecum are mediated by beta3-adrenoceptors.
机译：通过研究BRL37344，CGP12177和去甲肾上腺素的作用，研究了β-肾上腺素能介导的豚鼠Taenia盲肠松弛。这些药物引起豚鼠带盲肠的逐渐松弛。这些药物的浓度-反应曲线不受普萘洛尔，阿替洛尔，丁氧胺，吡唑嗪，育亨宾和酚妥拉明的影响。普萘洛尔使这些药物的浓度-反应曲线发生变化。对布萘洛尔针对BRL37344，CGP12177和去甲肾上腺素进行的Schild回归分析得出pA2值分别为5.79、5.61和5.53。在该制剂中，CGP12177和去甲肾上腺素显着增加了循环AMP的水平。普萘洛尔可显着降低CGP12177和去甲肾上腺素引起的环AMP含量，而普萘洛尔则无作用。这些结果表明，豚鼠带盲肠对BRL37344，CGP12177和去甲肾上腺素的松弛反应是由β3-肾上腺素受体介导的。

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