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首页> 外文期刊>Life sciences >Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients.
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Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients.

机译：一组原发性高血压患者的淋巴细胞内游离镁，钙和胰岛素耐受性测试。

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In order to assess the links which are claimed to exist between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT) in a group of 16 normotensive control subjects (NC) and 34 essential hypertensive subjects (EH). Mg(i) and Ca(i) were measured in triplicate by means of a fluorimetric technique based on the dyes furaptra and fura-2 respectively. K(itt) values proved significantly reduced in EH as compared to NC (M +/- SD, EH: 4.49 +/- 1.31 vs 5.28 +/- 1.19, P <0.05; 95% confidence limits: 0.23-1.5). Mg(i) and Ca(i) were not statistically different in EH as compared to NC subjects (Mg(i), NC: 266 +/- 20 micromol/l; EH: 245 +/- 50 micromol/l; Ca(i), NC: 47 +/- 9 nmol/l EH: 46 +/- 13 nmol/l). We found a statistically significant inverse correlation in the whole study group between K(itt) and body mass index (R= -0.363, P<0.01) and a statistically significant positive correlation between K(itt) and Mg(i) (R=0.347, P=0.013) was found. In a step-up multivariate regression analysis including blood pressure, plasma lipids, BMI, plasma magnesium, fasting insulin, fasting glucose, Mg(i) and Ca(i), the dependent variable K(itt) is statistically significantly correlated with body mass index and Mg(i). In a first attempt to study the relationships between insulin resistance, Mg(i) and Ca(i) in nucleated cells, the chosen index of peripheral resistance seems to be linked to intracellular free magnesium.
机译：为了评估据称存在于外周胰岛素抵抗与细胞内镁和钙浓度之间的联系，我们测量了游离淋巴细胞内镁（Mg（i））和钙（Ca（i））浓度以及血浆的速率常数在一组16名血压正常对照者（NC）和34名基本高血压受试者（EH）中，注射胰岛素（胰岛素耐受性测试：ITT）后血糖消失（K（itt））。 Mg（i）和Ca（i）分别通过一种荧光技术分别基于染料furaptra和fura-2进行三次测量。与NC相比，EH中的K（itt）值已显着降低（M +/- SD，EH：4.49 +/- 1.31与5.28 +/- 1.19，P <0.05; 95％置信度：0.23-1.5）。与NC受试者相比，EH中的Mg（i）和Ca（i）在统计学上没有统计学差异（Mg（i），NC：266 +/- 20 micromol / l; EH：245 +/- 50 micromol / l; Ca（ i），NC：47 +/- 9nmol / l EH：46 +/- 13nmol / l）。我们在整个研究组中发现K（itt）和体重指数之间存在统计学上的显着负相关（R = -0.363，P <0.01），而K（itt）和Mg（i）之间存在统计学上的显着正相关（R = 0.347，P = 0.013）。在包括血压，血浆脂质，BMI，血浆镁，空腹胰岛素，空腹血糖，Mg（i）和Ca（i）的逐步多元回归分析中，因变量K（itt）在统计学上与体重显着相关指数和Mg（i）。在首次研究有核细胞中胰岛素抵抗，Mg（i）和Ca（i）之间的关系时，外周抵抗的选定指标似乎与细胞内游离镁有关。

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