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Expression of lymphocyte subpopulations, cytokine serum levels and blood and urine trace elements in nickel sensitised women.

机译:镍致敏妇女中淋巴细胞亚群,细胞因子血清水平以及血液和尿微量元素的表达。

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In this study, 20 non-allergic and 20 non-atopic women sensitised only to nickel (Ni) showed similar levels of urine and serum Ni and serum chromium (Cr). On the contrary, serum copper, a marker of inflammation, was significantly higher in the Ni-sensitised group. Sensitised women also had higher values of blood B CD19+, CD5--CD19+ and B and natural killer CD3--CD25+ lymphocytes, but not alterations of some other lymphocyte subsets and serum cytokines. Urine Ni was correlated with "memory" CD4+-CD45RO+ lymphocytes in the non-allergic women and with T CD4+-CD45RO+ and CD3+-CD25+ cells in the atopic women; these subjects also showed a statistically significant correlation of serum Ni with B CD5+-CD19+ lymphocytes and serum IL-13. Moreover, serum Cr of both groups of women was positively or negatively correlated with activated HLA-DR+ cells and/or serum IL-5 and interferon gamma. These results (confirming in part those of a previous study on non-allergic men) suggest that both Ni and Cr are involved in mechanisms regulating the immune response and that allergy to these metals could be considered an alteration of their physiological role.
机译:在这项研究中,仅对镍(Ni)敏感的20名非过敏性妇女和20名非过敏性妇女的尿液和血清Ni和血清铬(Cr)含量相似。相反,在镍致敏组中,血清铜(一种炎症标志物)明显更高。敏感妇女的血B CD19 +,CD5--CD19 +和B以及自然杀伤CD3-CD25 +淋巴细胞的价值更高,但其他淋巴细胞亚群和血清细胞因子的改变则没有。尿镍与非过敏性妇女的“记忆” CD4 + -CD45RO +淋巴细胞以及特应性妇女的T CD4 + -CD45RO +和CD3 + -CD25 +细胞相关。这些受试者还显示血清Ni与B CD5 + -CD19 +淋巴细胞和血清IL-13在统计学上显着相关。此外,两组女性的血清Cr与活化的HLA-DR +细胞和/或血清IL-5和干扰素γ呈正相关或负相关。这些结果(部分证实了先前对非过敏性男性的研究结果)表明,镍和铬均参与调节免疫应答的机制,对这些金属的过敏可被视为其生理作用的改变。

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