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首页> 外文期刊>Life sciences >Antipruritic effect of millimeter waves in mice: evidence for opioid involvement.
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Antipruritic effect of millimeter waves in mice: evidence for opioid involvement.

机译：毫米波对小鼠的止痒作用：阿片类药物参与的证据。

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摘要

In our previous studies, exposure of mice to millimeter waves (MW) increased the duration of anesthesia caused by either ketamine or chloral hydrate, and this effect was blocked by naloxone. To further characterize the biological effects of MW, we have chosen a new animal model of experimental itch. Male Swiss albino mice were injected s.c. in the rostral part of the back with the pruritogenic agent, compound 48/80, with or without naloxone pretreatment. After a 15-min exposure of mice to MW (frequency, 61.22 GHz; incident power density, 15 mW/cm2), the number of scratches of the injected site was counted for 90 min post-injection. MW inhibited the scratching activity of mice by more than 2 times in comparison with the sham-exposed controls (p<0.005). Pretreatment of animals with (-)-naloxone (0.1-1.0 mg/kg, i.p.) suppressed the antipruritic effect of MW in a dose-dependent manner, while the inactive enantiomer (+)-naloxone at 1 mg/kg did not alter the effect. These results suggest that MW trigger the release of opioids in exposed subjects.
机译：在我们以前的研究中，将小鼠暴露于毫米波（MW）会增加由氯胺酮或水合氯醛引起的麻醉时间，而这种作用被纳洛酮所阻断。为了进一步表征MW的生物学效应，我们选择了实验性瘙痒的新动物模型。雄性瑞士白化病小鼠经皮下注射。配合或不配合纳洛酮预处理的普鲁司通剂，化合物48/80，在背部的前额部分。将小鼠暴露于MW（频率为61.22 GHz;入射功率密度为15 mW / cm2）15分钟后，在注射后90分钟内计数注射部位的划痕数。与假接触的对照组相比，MW抑制小鼠的抓挠活性超过2倍（p <0.005）。用（-）-纳洛酮（0.1-1.0 mg / kg，ip）预处理动物以剂量依赖的方式抑制了MW的止痒作用，而1 mg / kg的无活性对映体（+）-纳洛酮并未改变影响。这些结果表明，MW触发了暴露对象中阿片样物质的释放。

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