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首页> 外文期刊>Life sciences >Benzodiazepine effects on human sleep EEG spectra: a comparison of triazolam and flunitrazepam.
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Benzodiazepine effects on human sleep EEG spectra: a comparison of triazolam and flunitrazepam.

机译：苯二氮卓类药物对人类睡眠脑电图的影响：三唑仑和氟尼西epa的比较。

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摘要

The effects of 0.5 mg triazolam (TRI) and 4 mg flunitrazepam (FNZ) on the sleep electroencephalogram (EEG) were studied in eleven (six for TRI, and five for FNZ) healthy young male subjects. C3 EEG channel data of one baseline night, three drug nights and two withdrawal nights were recorded and their analyzed using a fast Fourier transformation (FFT) method. Changes in the 0.5 Hz to 40 Hz power spectrum showed that: 1) both TRI and FNZ increased higher frequency activity and reduced lower frequency activity on the drug nights; 2) on drug nights, NREM sigma frequency power was more strongly enhanced by TRI than FNZ, while the beta power of both NREM and REM was more strongly enhanced by FNZ than TRI; 3) NREM alpha power increased on the second night of withdrawal from both TRI and FNZ; 4) the power spectra for both NREM and REM sleep returned to baseline levels by the fourth night of withdrawal from either TRI or FNZ. These findings suggest that 0.5 mg TRI and 4 mg FNZ have both common and differing pharmacological effects on the central nervous system. Such differences could be caused by differences in the dose, half-life or systemic distribution of these two drugs.
机译：在11名健康男性男性（6名TRI，5名FNZ）中研究了0.5 mg三唑仑（TRI）和4 mg氟硝西epa（FNZ）对睡眠脑电图（EEG）的影响。记录一个基准夜，三个药物夜和两个撤药夜的C3 EEG通道数据，并使用快速傅里叶变换（FFT）方法对其进行分析。 0.5 Hz至40 Hz功率谱的变化表明：1）TRI和FNZ在毒品之夜均增加了高频活动，并降低了低频活动; 2）在药物之夜，TRI比FNZ增强NREM sigma频率功率，而FNZ比TRI增强NREM和REM的β功率。 3）从TRI和FNZ撤出的第二天晚上，NREM alpha功率增加; 4）从TRI或FNZ撤出的第四个晚上，NREM和REM睡眠的功率谱均恢复到基线水平。这些发现表明0.5 mg TRI和4 mg FNZ对中枢神经系统具有共同的和不同的药理作用。这种差异可能是由于这两种药物的剂量，半衰期或全身分布不同而引起的。

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