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首页> 外文期刊>Life sciences >The effect of cyclosporine administration on growth hormone release and serum concentrations of insulin-like growth factor-I in male rats.
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The effect of cyclosporine administration on growth hormone release and serum concentrations of insulin-like growth factor-I in male rats.

机译：环孢霉素对雄性大鼠生长激素释放和胰岛素样生长因子-I血清浓度的影响。

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摘要

The aim of this work was to study the effect of cyclosporine on the somatotropic axis. Accordingly, growth hormone (GH) secretion, circulating insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBPs) in response to cyclosporin A (CsA) treatment were examined in adult male Wistar rats. Cyclosporine administration (5, 10 or 20 mg/Kg daily) over 8 days did not modify the body weight, but it did decrease serum concentration of corticosterone and increased serum IGF-I and GH levels. Rats treated with 5 and 10 mg/Kg of cyclosporine had similar levels of serum IGFBPs to control rats, but there was an increase in circulating IGFBP-3 and IGFPB-1,2 in the group treated with 20 mg/Kg of CsA. The increase in circulating GH correlates with a decrease in pituitary GH content in CsA treated rats, with no modification in hypothalamic somatostatin content, suggesting an increase in pituitary GH release. In order to test this hypothesis, anterior pituitary cell cultures were exposed to different CsA concentrations during a 4 h incubation period. Cyclosporine increased GH secretion in cultured pituitary cells (p<0.05). These data suggest that cyclosporine increases circulating IGF-I and GH by stimulating pituitary GH release.
机译：这项工作的目的是研究环孢素对促生长轴的影响。因此，在成年雄性Wistar大鼠中检查了响应环孢菌素A（CsA）治疗的生长激素（GH）分泌，循环胰岛素样生长因子I（IGF-1）和IGF结合蛋白（IGFBPs）。连续8天服用环孢霉素（每天5、10或20 mg / Kg）不会改变体重，但确实会降低皮质酮的血清浓度并增加血清IGF-I和GH水平。用5和10 mg / Kg环孢素治疗的大鼠血清IGFBP的水平与对照大鼠相似，但是用20 mg / Kg CsA治疗的组中循环IGFBP-3和IGFPB-1,2的升高。在经CsA处理的大鼠中，循环GH的升高与垂体GH含量的降低有关，而下丘脑生长抑素含量没有改变，表明垂体GH释放的增加。为了检验该假设，在4 h的孵育期间将垂体前叶细胞培养物暴露于不同的CsA浓度。环孢霉素可增加培养的垂体细胞中GH的分泌（p <0.05）。这些数据表明环孢菌素通过刺激垂体GH释放而增加循环IGF-1和GH。

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