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首页> 外文期刊>Life sciences >Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2.
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Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2.

机译：男性基因型ALDH2的酒精摄入过程中αEEG的偶极估计。

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Using a dipole tracing method based on the two-dipole model, the purpose of the present study was to investigate alcohol-induced changes in the alpha band of electroencephalogram (EEG) and its equivalent current dipoles (ECDs) in 12 healthy male volunteers, who were genetically typed for mitochondrial aldehyde dehydrogenase-2 (ALDH2). The alpha power and the mean interval dipolarity, which represents the goodness of fit of alpha EEG with the two-dipole model, increased at 30 min after 0.75 ml/kg of alcohol ingestion, when breath alcohol concentration showed its peak. However, the location of ECDs and distribution of alpha EEG did not change after alcohol ingestion. These findings indicate that alcohol enhances alpha EEG but does not change the location of its electrical sources. Interestingly, the time course of alcohol-induced EEG changes differed significantly according to the aversive flushing reaction after its intake. From 60 to 120 min, the non-flushing group which had homozygous ALDH2* 1 (active type) displayed significant increase not only in the alpha power but also in the interval dipolarity compared to the baseline, whereas the flushing group with heterozygous ALDH2*1/2*2 (inactive type) did not exhibit this significant increase. The difference in the time course was discussed from the viewpoint of the protective effect of ALDH2*2 allele against the risk for alcoholism. These results suggest that the dipole tracing method could provide an alternative neurophysiological marker for the risk for alcoholism.
机译：使用基于双偶极子模型的偶极子追踪方法，本研究的目的是调查12名健康男性志愿者中酒精引起的脑电图（EEG）和等效电流偶极子（ECD）的α带变化。线粒体醛脱氢酶2（ALDH2）的基因类型。 0.75 ml / kg的酒精摄入量于30分钟后（呼吸酒精浓度达到峰值），α功率和平均间隔偶极性（代表αEEG与两偶极子模型拟合的良好性）增加。但是，摄入酒精后，ECD的位置和αEEG的分布没有改变。这些发现表明，酒精可增强αEEG，但不会改变其电源位置。有趣的是，酒精引起的脑电图变化的时间过程根据摄入后的厌恶性潮红反应而显着不同。从60到120分钟，与基线相比，具有纯合的ALDH2 * 1（活性型）的非冲洗组不仅在α功率方面而且在间隔偶极性方面均显示显着增加，而具有杂合的ALDH2 * 1的冲洗组/ 2 * 2（非活动类型）没有显示出明显的增加。从ALDH2 * 2等位基因对酒精中毒风险的保护作用的角度讨论了时程上的差异。这些结果表明，偶极子追踪方法可以为酒精中毒的风险提供替代的神经生理学标记。

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