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首页> 外文期刊>Life sciences >Inhibition of brain monoamine oxidase activity by the generation of hydroxyl radicals: potential implications in relation to oxidative stress.
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Inhibition of brain monoamine oxidase activity by the generation of hydroxyl radicals: potential implications in relation to oxidative stress.

机译：羟基自由基的产生抑制脑单胺氧化酶活性：与氧化应激有关的潜在影响。

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摘要

Monoamine oxidase (MAO) is an enzyme involved in brain catabolism of monoamine neurotransmitters whose oxidative deamination results in the production of hydrogen peroxide. It has been documented that hydrogen peroxide derived from MAO activity represents a special source of oxidative stress in the brain. In this study we investigated the potential effects of the production of hydroxyl radicals (*OH) on MAO-A and MAO-B activities using mitochondrial preparations obtained from rat brain. Ascorbic acid (100 microM) and Fe2+ (0.2, 0.4, 0.8, and 1.6 microM) were used to induce the production of *OH. Results showed that the generation of *OH significantly reduced both MAO-A (85-53%) and MAO-B (77-39%) activities, exhibiting a linear correlation between both MAO-A and MAO-B activities and the amount of *OH produced. The reported inhibition was found to be irreversible for both MAO-A and MAO-B. Assuming the proven contribution of MAO activity to brain oxidative stress, this inhibition appears to reduce this contribution when an overproduction of *OH occurs.
机译：单胺氧化酶（MAO）是一种参与单胺神经递质的脑分解代谢的酶，其氧化脱氨作用导致产生过氧化氢。已有文献证明，源自MAO活性的过氧化氢是大脑中氧化应激的特殊来源。在这项研究中，我们研究了使用从大鼠脑中获得的线粒体制剂，对羟自由基（* OH）的产生对MAO-A和MAO-B活性的潜在影响。抗坏血酸（100 microM）和Fe2 +（0.2、0.4、0.8和1.6 microM）用于诱导* OH的生成。结果表明* OH的产生显着降低了MAO-A（85-53％）和MAO-B（77-39％）的活性，在MAO-A和MAO-B活性与MAO-B量之间呈线性关系。 * OH产生。发现所报道的抑制作用对于MAO-A和MAO-B都是不可逆的。假设已证明MAO活性对脑氧化应激的贡献，当* OH过量产生时，这种抑制作用似乎会减少这种贡献。

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