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首页> 外文期刊>Life sciences >Opiate-like substances mediate norepinephrine-induced but not serotonin-induced antinociception at spinal level: reevaluation by an electrophysiological model of formalin test in rats.
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Opiate-like substances mediate norepinephrine-induced but not serotonin-induced antinociception at spinal level: reevaluation by an electrophysiological model of formalin test in rats.

机译：阿片样物质在脊髓水平上介导去甲肾上腺素诱导的但不是5-羟色胺诱导的抗伤害感受：通过福尔马林试验的电生理模型对大鼠进行重新评估。

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摘要

After subcutaneous injection of formalin (5%, 50 microl) into a hindpaw of rats, biphasic excitatory nociceptive discharges were recorded extracellularly in thalamic parafascicular neurons. Intrathecal (i.t.) administration of either norepinephrine (NE. 6 nmol, 10 microl) or serotonin (5-HT, 120 nmol, 10 microl) prior to the second phase significantly inhibited the second phase of the formalin-induced parafascicular nociceptive discharges. Intrathecal naloxone (Nal, 50 nmol, 10 microl) did not show any effect on the parafascicular nociceptive discharges. However, when i.t. Nal was given 5 min before NE, Nal prevented the NE antinociceptive effect. Pre-administration of Nal before 5-HT did not affect the antinociceptive effects of 5-HT on the second phase of nociceptive discharges. These results indicate that opiate-like substances are involved in the mediation of NE-induced antinociception. It is suggested that endogenous NE and 5-HT released from brainstem descending terminals at the spinal level carry out their antinociceptive actions differently.
机译：在大鼠后足皮下注射福尔马林（5％，50微升）后，丘脑束旁神经元在细胞外记录了双相兴奋性伤害性放电。在第二阶段之前先鞘内（i.t.）施用去甲肾上腺素（NE。6 nmol，10微升）或血清素（5-HT，120 nmol，10微升）可显着抑制福尔马林诱导的束旁伤害性放电的第二阶段。鞘内纳洛酮（Nal，50 nmol，10微升）对束旁伤害性放电无任何影响。但是，当Nal在NE前5分钟给予，Nal预防NE抗伤害感受作用。在5-HT之前预先使用Nal不会影响5-HT对伤害性放电第二阶段的抗伤害感受作用。这些结果表明，鸦片样物质参与NE诱导的抗伤害感受的介导。提示从脑干下降末端在脊髓水平释放的内源性NE和5-HT的抗伤害作用不同。

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