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首页> 外文期刊>Life sciences >Different role of endotheliumitric oxide in 17beta-estradiol- and progesterone-induced relaxation in rat arteries.
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Different role of endotheliumitric oxide in 17beta-estradiol- and progesterone-induced relaxation in rat arteries.

机译：内皮/一氧化氮在17β-雌二醇和孕酮诱导的大鼠动脉松弛中的不同作用。

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摘要

The present study was aimed to examine the different role of endotheliumitric oxide in relaxation induced by two female sex hormones, 17beta-estradiol and progesterone in rat isolated aortas and mesenteric arteries. The isometric force of each ring was measured with Grass force-displacement transducers in the organ bathes. 17beta-Estradiol induced both endothelium-dependent and -independent relaxation in the rat aortas but only the endothelium-independent relaxation in the rat mesenteric arteries. In contrast. progesterone induced both endothelium-dependent and -independent relaxation in the rat mesenteric arteries but only endothelium-independent relaxation in rat aortas. N(G)-Nitro-L-arginine methyl ester and methylene blue attenuated the relaxant response to 17beta-estradiol in the aortic rings or to progesterone in the mesenteric arteries. Pretreatment with L-arginine antagonized the effect of N(G)-nitro-L-arginine methyl ester on sex hormone-induced relaxation. The endothelium contribution to relaxation seems to only relate to lower concentrations of 17beta-estradiol and progesterone. In summary, the present results clearly demonstrate a different role of the functional endothelium in the relaxant response to 17beta-estradiol or progesterone in the conduit vessel (aorta) and the resistance vessels (mesenteric artery). Nitric oxide contributes largely to the endothelium-dependent relaxation induced by 17beta-estradiol in the isolated aortas or by progesterone in the mesenteric arteries.
机译：本研究旨在检查内皮/一氧化氮在大鼠离体主动脉和肠系膜动脉中由两种女性性激素17β-雌二醇和孕酮诱导的放松中的不同作用。每个环的等距力是通过器官浴中的格拉斯位移传感器测量的。 17β-雌二醇可在大鼠主动脉中诱导内皮依赖性和非依赖性舒张，但仅在大鼠肠系膜动脉中诱导非内皮依赖性舒张。相反。黄体酮在大鼠肠系膜动脉中诱导内皮依赖性和非依赖性松弛，但在大鼠主动脉中仅诱导非内皮依赖性的松弛。 N（G）-硝基-L-精氨酸甲酯和亚甲基蓝可减弱对主动脉环中17β-雌二醇或对肠系膜动脉中孕酮的松弛反应。 L-精氨酸预处理可拮抗N（G）-硝基-L-精氨酸甲酯对性激素诱导的松弛的影响。内皮对松弛的贡献似乎仅与较低浓度的17β-雌二醇和孕酮有关。总之，本发明结果清楚地证明了功能性内皮在导管血管（主动脉）和阻力血管（肠系膜动脉）对17β-雌二醇或孕酮的松弛反应中的不同作用。一氧化氮对分离的主动脉中的17β-雌二醇或肠系膜动脉中的孕酮诱导的内皮依赖性舒张作用很大。

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