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首页> 外文期刊>Life sciences >Fasting stress exacerbates classical conditioned histamine release in guinea pigs.
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Fasting stress exacerbates classical conditioned histamine release in guinea pigs.

机译：空腹应激会加剧豚鼠的经典条件性组胺释放。

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摘要

To clarify the contribution of stress to classical conditioning-associated asthmatic responses, the effect of fasting stress on conditioned histamine release was investigated in a guinea pig model of asthma. The animals were randomly divided into 2 groups for Experiment 1 and 2, and received a conditioning procedure in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (DMS, sulfur smelling) as a conditioned stimulus (CS) were simultaneously inhaled after fasting for 16 h. Then, one group was given food as a reward for respiratory distress, and the other group was denied it for more than 3 h, while being placed in front of the feeding group. After this procedure was repeated 5 times, the plasma histamine levels in response to the CS were measured in half of each group in Experiment 1, and the respiratory resistance (Rrs) was assessed similarly in the other half of each group in Experiment 2. The same experiments were again performed after exchanging assignments of feeding group or fasting group in both experiments. The control groups in both experiments received the CS and the US 10 times separately in a random order under 16 h fasting conditions and were provided food after the exposures. After these pseudo-conditioning presentations, the plasma histamine levels or the Rrs in response to the CS were measured. In Experiment 1, the plasma histamine levels in the fasting stress group after the first conditioning sessions were significantly higher than those of the other groups. This difference was not observed when the groups were exchanged. In Experiment 2, the fasting stress group showed higher values in the Rrs compared to the other groups, irrespective of the first or second conditionings; however, they were not significant. The present study indicates that fasting stress after the conditioning procedures exacerbates the following conditioned histamine release, although the stress effect on bronchoconstriction was not confirmed.
机译：为了阐明应激对经典条件相关哮喘反应的影响，在豚鼠哮喘模型中研究了空腹应激对条件组胺释放的影响。将动物随机分为实验1和2的两组，并接受调节程序，其中同时吸入卵白蛋白（OA）作为无条件刺激（US）和二甲基硫醚（DMS，硫磺味）作为有条件刺激（CS）禁食16小时后。然后，一组被给予食物以奖励呼吸窘迫，另一组被拒食超过3小时，同时被置于喂养组的前面。重复此步骤5次后，在实验1中每组的一半中测量对CS的血浆组胺水平，在实验2中每组的另一半中相似地评估呼吸阻力（Rrs）。在两个实验中交换进食组或禁食组的分配后，再次进行相同的实验。在两个实验中，对照组均在禁食16小时的条件下随机接受CS和US 10次，并在暴露后提供食物。在这些伪条件表示之后，测量血浆组胺水平或响应CS的Rrs。在实验1中，首次条件训练后的空腹应激组血浆组胺水平明显高于其他组。交换组时未观察到这种差异。在实验2中，与第一组或第二组条件无关，与其他组相比，空腹应激组的Rrs值更高。但是，它们并不重要。本研究表明，调理程序后的空腹应激加剧了以下条件化组胺的释放，尽管尚未证实对支气管收缩的应激作用。

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