Differences of mu-opioid receptors between Lewis and F344 rats.

Herradon G; Morales L; Alguacil LF

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Differences of mu-opioid receptors between Lewis and F344 rats.

机译：Lewis和F344大鼠之间的μ阿片受体的差异。

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F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific mu-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of mu-opioid receptors. The density of [H3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for mu-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that mu-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity.

机译：F344和Lewis大鼠在几种实验范例中显示出对阿片类药物的不同反应。在这项研究中，我们使用了特定的阿片类药物激动剂DAMGO来确定这些差异是否可归因于阿片类药物受体的异质性。 [H3] DAMGO结合位点的密度在两种菌株的大脑皮层和脊髓中相似，但是在F344组织中，DAMGO对μ阿片受体的亲和力更高。此外，一项关于DAMGO对分离的瓦萨铁素体电诱发抽搐的作用的平行研究表明，该药物在F344制剂中也更有效。这些结果表明F344大鼠的μ阿片受体对体外药理刺激更敏感，这可能与更高的药物亲和力有关。

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《Life sciences》 |2003年第12期|共6页
作者
Herradon G; Morales L; Alguacil LF;
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正文语种 eng
中图分类基础医学;
关键词
Analgesics; Opioid; Brain; Enkephalin; Ala(2)-MePhe(4)-Gly(5)-; Receptors; Opioid; mu; 镇痛药; 阿片类; 脑; 受体; 阿片样; μ;

机译：Analgesics;Opioid;Brain;Enkephalin;Ala(2)-MePhe(4)-Gly(5)-;Receptors;Opioid;mu;镇痛药;阿片类;脑;受体;阿片样;μ;

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专利

1. Differences of mu-opioid receptors between Lewis and F344 rats. [J] . Herradon G, Morales L, Alguacil LF Life sciences . 2003,第12期

机译：Lewis和F344大鼠之间的μ阿片受体的差异。
2. Genetic differences in NMDA and D1 receptor levels, and operant responding for food and morphine in Lewis and Fischer 344 rats. [J] . Martin S, Lyupina Y, Crespo JA, Brain research . 2003,第2期

机译：Lewis和Fischer 344大鼠中NMDA和D1受体水平的遗传差异以及对食物和吗啡的操作性响应。
3. Age-related change and its sex differences in histoarchitecture of the hypothalamic suprachiasmatic nucleus of F344/N rats. [J] . Tsukahara S, Tanaka S, Ishida K, Experimental Gerontology . 2005,第3期

机译：F344 / N大鼠下丘脑视交叉上核的组织结构中的年龄相关变化及其性别差异。
4. Polymorphisms in the mu-Opioid Receptor Gene in Jordanian Arabs with Opiate Drug Dependence [C] . AL-Eitan L.N., Jaradat S.A., Dadour I.R., International Conference on Environmental Stressors in Biology and Medicine . 2012

机译：Jordanian Arabs的Mu-Apioid受体基因的多态性，具有鸦片药物依赖性
5. Involvement of the estrogen receptor and aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovotoxicity in F344 rats. [D] . Thompson, Kary Ellen. 2001

机译：雌激素受体和芳基烃受体参与F344大鼠4-乙烯基环己烯二环氧化合物诱导的卵毒性。
6. Serum antibody does not account for differences in the severity of chronic respiratory disease caused by Mycoplasma pulmonis in LEW and F344 rats. [O] . J W Simecka, J K Davis, G H Cassell 1989

机译：血清抗体不能解释LEW和F344大鼠中肺炎支原体引起的慢性呼吸系统疾病严重程度的差异。
7. Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats. [O] . Wilder, R L, Allen, J B, Hansen, C 1987

机译：胸腺依赖性和非依赖性调节链球菌细胞壁诱导的关节炎大鼠滑膜中Ia抗原表达的细胞。在正常胸腺，无胸腺和环孢菌素A治疗的LEW和F344大鼠中，部位和表达强度的差异。

Differences of mu-opioid receptors between Lewis and F344 rats.

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