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首页> 外文期刊>Life sciences >Effect of age increase on metabolism and toxicity of ethanol in female rats.
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Effect of age increase on metabolism and toxicity of ethanol in female rats.

机译：年龄增长对雌性大鼠乙醇代谢和毒性的影响。

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Age-dependent change in the effects of acute ethanol administration on female rat liver was investigated. Female Sprague-Dawley rats, each aged 4, 12, or 50 weeks, received ethanol (2 g/kg) via a catheter inserted into a jugular vein. Ethanol elimination rate (EER), most rapid in the 4 weeks old rats, was decreased as the age advanced. Hepatic alcohol dehydrogenase activity was not altered by age, but microsomal p-nitrophenol hydroxylase activity was significantly greater in the 4 weeks old rats. Relative liver weight decreased with age increase in proportion to reduction of EER. Hepatic triglyceride and malondialdehyde concentrations increased spontaneously in the 50 weeks old nai;ve rats. Ethanol administration (3 g/kg, ip) elevated malondialdehyde and triglyceride contents only in the 4 and the 12 weeks old rats. Hepatic glutathione concentration was increasingly reduced by ethanol with age increase. Ethanol decreased cysteine concentration in the 4 weeks old rats, but elevated it significantly in the older rats. Inhibition of gamma-glutamylcysteine synthetase activity by ethanol was greater with age increase, which appeared to be responsible for the increase in hepatic cysteine. The results indicate that age does not affect the ethanol metabolizing capacity of female rat liver, but the overall ethanol metabolism is decreased in accordance with the reduction of relative liver size. Accordingly induction of acute alcoholic fatty liver is less significant in the old rats. However, progressively greater depletion of glutathione by ethanol in older rats suggests that susceptibility of liver to oxidative damage would be increased as animals grow old.
机译：研究了急性乙醇给药对雌性大鼠肝脏的年龄依赖性变化。雌性Sprague-Dawley大鼠每只年龄分别为4、12或50周，通过插入颈静脉的导管接受乙醇（2 g / kg）。乙醇消除率（EER）（在4周龄大鼠中最快）随着年龄的增长而降低。肝醇脱氢酶活性未随年龄而改变，但在4周龄大鼠中，微粒体对硝基苯酚羟化酶活性明显更高。肝脏的相对重量随着年龄的增加而减少，与EER的减少成正比。在50周龄的新生大鼠中，肝脏甘油三酸酯和丙二醛的浓度自发增加。乙醇给药（3 g / kg，腹腔注射）仅在4周和12周龄大鼠中升高了丙二醛和甘油三酸酯的含量。随着年龄的增长，肝脏中谷胱甘肽的浓度逐渐降低。乙醇降低了4周龄大鼠的半胱氨酸浓度，但在老年大鼠中使半胱氨酸浓度显着升高。随着年龄的增长，乙醇对γ-谷氨酰半胱氨酸合成酶活性的抑制作用更大，这似乎是肝半胱氨酸增加的原因。结果表明，年龄不影响雌性大鼠肝脏的乙醇代谢能力，但是总乙醇代谢随肝脏相对大小的减少而降低。因此，在老年大鼠中急性酒精性脂肪肝的诱导意义不大。然而，在老年大鼠中，乙醇对谷胱甘肽的消耗越来越大，这表明随着动物年龄的增长，肝脏对氧化损伤的敏感性会增加。

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