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首页> 外文期刊>Life sciences >Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis.
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Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis.

机译：大蒜粉饮食在二乙基亚硝胺诱导的大鼠肝癌发生中的化学预防作用。

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摘要

This study was conducted to examine the effects of dietary garlic powder at the different levels on preneoplastic foci formation and glutathione (GSH)-dependent detoxifying enzyme activities in rat hepatocarcinogenesis. Male Sprague-Dawley rats were fed with garlic powder supplemented diets (0, 0.5, 2.0 or 5.0%) for 11 weeks, and induced hepatocarcinogenesis by diethylnitrosamine (DEN) and two-thirds partial hepatectomy in medium-term bioassay system. The 2.0 and 5.0% garlic powder diets suppressed the formation of placental GSH S-transferase positive (GST-P(+)) foci in number (49.7 and 63.1% of DEN-treated control group, respectively) and area (44.2 and 63.9% of DEN-treated control group, respectively). Total GSH content in 2.0% garlic powder diet group was 1.2 fold higher than that in DEN-treated control group. GSH S-transferase activity of 2.0% garlic powder diet group was lower than that in DEN-treated control group, and GSH peroxidase (GPx) activity was significantly increased by garlic powder diets (83 and 164% of DEN-treated control group, respectively). GSH reductase activity, however, did not show a noticeable difference among groups. Therefore, the suppression of GST-P(+) foci formation by garlic powder diets could be partly affected by the increase of total GSH content and GPx activity.
机译：进行了这项研究，以研究不同剂量的膳食大蒜粉对大鼠肝癌发生中肿瘤前灶形成和谷胱甘肽（GSH）依赖性解毒酶活性的影响。在中期生物测定系统中，雄性Sprague-Dawley大鼠接受大蒜粉补充饮食（0％，0.5％，2.0％或5.0％）喂养11周，并通过二乙基亚硝胺（DEN）和三分之二的部分肝切除术诱导肝癌发生。 2.0％和5.0％大蒜粉饮食抑制了胎盘GSH S-转移酶阳性（GST-P（+））病灶的形成（分别为DEN处理对照组的49.7和63.1％）和面积（44.2和63.9％）分别为DEN治疗的对照组）。 2.0％大蒜粉饮食组的总GSH含量比DEN治疗的对照组高1.2倍。 2.0％大蒜粉饮食组的GSH S-转移酶活性低于DEN处理的对照组，而GSH过氧化物酶（GPx）活性显着增加（分别为DEN处理对照组的83％和164％） ）。然而，GSH还原酶活性在各组之间没有显示出明显的差异。因此，大蒜粉饮食对GST-P（+）灶形成的抑制可能部分受到总GSH含量和GPx活性增加的影响。

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