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首页> 外文期刊>Life sciences >Effect of acute hyperglycemia on basal, secretin and secretin + cholecystokinin stimulated exocrine pancreatic secretion in humans.
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Effect of acute hyperglycemia on basal, secretin and secretin + cholecystokinin stimulated exocrine pancreatic secretion in humans.

机译：急性高血糖对人基础，促胰液素和促胰液素+胆囊收缩素刺激的外分泌胰腺分泌的影响。

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Pancreatico-biliary secretion is reduced during acute hyperglycemia. We investigated whether alterations in pancreatico-biliary flow or volume output are responsible for the observed reduction in duodenal output of pancreatic enzymes and bilirubin during hyperglycemia. Eight healthy subjects were studied on two occasions during normoglycemia and hyperglycemia (15 mmol/l). Pancreatico-biliary output was measured by aspiration using a recovery marker under basal conditions (60 min), during secretin infusion (0.1 CU/kg.h) for 60 min and during secretin + CCK (0.5 IDU/kg.h) infusion for 60 min. Secretin was infused to stimulate pancreatico-biliary flow and volume output. Secretin significantly (P<0.005-P<0.05) increased volume and bicarbonate output and CCK significantly (P<0.01) increased the output of bilirubin, pancreatic enzymes, bicarbonate and volume, both during normoglycemia and hyperglycemia. During hyperglycemia basal, secretin stimulated and secretin + CCK stimulated total pancreatico-biliary output were significantly (P<0.005-P<0.05) reduced compared to normoglycemia. The incremental outputs, however, were not significantly different between hyper- and normoglycemia. Pancreatic volume output was significantly (P<0.05) reduced during hyperglycemia compared to normoglycemia under basal conditions (31+/-16 m/h versus 132+/-33 m/h) during secretin infusion (130+/-17 ml/h versus 200+/-34 m/h) and during secretin + CCK infusion (370+/-39 ml/h versus 573+/-82 ml/h). Plasma PP levels were significantly (P<0.05) reduced during hyperglycemia. It is concluded that 1) hyperglycemia significantly reduces basal pancreatico-biliary output 2) the incremental pancreaticobiliary output in response to secretin or secretin + CCK infusion is not significantly affected during hyperglycemia, 3) a reduction in volume output contributes to the inhibitory effect of hyperglycemia on pancreatico-biliary secretion, 4) hyperglycemia reduces PP secretion suggesting vagal-cholinergic inhibition of pancreatico-biliary secretion and volume during hyperglycemia.
机译：急性高血糖时胰胆汁分泌减少。我们调查了高血糖期间胰腺胆道流量或体积输出的变化是否导致了胰酶和胆红素的十二指肠输出减少。在正常血糖和高血糖（15 mmol / l）期间两次研究了八名健康受试者。在基础条件下（60分钟），在促胰液素输注（0.1 CU / kg.h）期间60分钟和在促胰液素+ CCK（0.5 IDU / kg.h）输注60分钟期间，使用恢复标记通过抽吸来测量胰胆量。分钟注入促胰液素以刺激胰胆流量和体积输出。在正常血糖和高血糖期间，促胰液素显着（P <0.005-P <0.05）增加了体积和碳酸氢盐的输出，而CCK显着（P <0.01）增加了胆红素，胰腺酶，碳酸氢盐和体积的输出。在基础高血糖期间，与正常血糖相比，促胰液素刺激和促胰液素+ CCK刺激的总胰胆总产量显着降低（P <0.005-P <0.05）。然而，高血糖和正常血糖之间的增量输出没有显着差异。与基础血糖正常血糖水平下的正常血糖相比（31 +/- 16 m / h与132 +/- 33 m / h），高血糖过程中的胰腺体积输出显着降低（P <0.05），而正常血糖水平则为正常血糖（130 +/- 17 ml / h） （200 +/- 34 m / h）和促胰液素+ CCK输注期间（370 +/- 39 ml / h对573 +/- 82 ml / h）。高血糖期间血浆PP水平显着降低（P <0.05）。结论是：1）高血糖显着降低基础胰胆量输出2）在高血糖过程中，对促胰液素或促胰液素+ CCK输注的胰胆量输出增加没有显着影响，3）减少体液输出有助于高血糖的抑制作用4）高血糖会降低PP的分泌，提示在高血糖时迷走胆碱能抑制胰腺胆汁的分泌和容量。

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