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首页> 外文期刊>Life sciences >The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures
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The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures

机译：三肽-铜复合糖基-L-组氨酸-L-赖氨酸-Cu2 +通过成纤维细胞培养刺激基质金属蛋白酶-2表达

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Glycyl-histidyl-lysine-Cu2+ (GHK-Cu) is a tripeptide-copper complex known to be a potent wound healing agent. We previously showed its ability to stimulate in vitro and in vivo the synthesis of extracellular matrix components. The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture. We showed that GHK-Cu increased MMP-2 levels in conditioned media of cultured fibroblasts. This effect was reproduced by copper ions but not by the tripeptide GHK alone. This stimulation was accompanied by an increase of MMP-2 mRNA level. We also showed that GHK-Cu increased the secretion of the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. Taken together, our results underline that GHK-Cu is not only an activator of connective tissue production but also of the remodeling of the extracellular matrix. It is able to modulate MMP expression by acting directly on wound ribroblasts. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 33]
机译：糖基-组氨酸-赖氨酸-Cu2 +（GHK-Cu）是一种三肽-铜复合物，已知是有效的伤口愈合剂。我们先前显示了它在体外和体内刺激细胞外基质成分合成的能力。本研究的目的是确定GHK-Cu对培养中真皮成纤维细胞MMP-2合成的影响。我们表明，GHK-Cu在培养的成纤维细胞的条件培养基中增加了MMP-2的水平。这种作用是由铜离子复制的，而不是由三肽GHK复制的。这种刺激伴随着MMP-2 mRNA水平的增加。我们还表明，GHK-Cu增加了金属蛋白酶，TIMP-1和TIMP-2的组织抑制剂的分泌。两者合计，我们的结果表明，GHK-Cu不仅是结缔组织生产的活化剂，而且还是细胞外基质重塑的活化剂。它能够通过直接作用于伤口的成核细胞上来调节MMP表达。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：33]

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