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首页> 外文期刊>Life sciences >Antioxidant actions of du-zhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules.
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Antioxidant actions of du-zhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules.

机译：杜仲（Eucommia ulmoides Oliv。）对生物分子氧化损伤的抗氧化作用。

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摘要

This study aimed to investigate the antioxidant effect of water extracts of Du-zhong (WEDZ) on oxidative damage in biomolecules such as deoxyribose, DNA, and 2'-deoxyguanosine (2'-dG) as induced by Fenton reaction. The WEDZ used included leaves, raw cortex, and roasted cortex. All of the WEDZ inhibited the oxidation of deoxyribose induced by Fe(3+)-EDTA/H2O2/ascorbic acid in a concentration dependent manner. At a concentration of 1.14 mg/mL, the inhibitory effect of the extracts of leaves, roasted cortex, and raw cortex was 85.2%, 68.0% and 49.3%, respectively. The extract of leaves inhibited the strand-breaking of DNA induced by the Fenton reaction at concentrations of 5 and 10 micrograms/microL. This inhibitory effect was similar to mannitol whereas the extracts of raw cortex and roasted cortex had no inhibitory effect at all. WEDZ also inhibited the oxidation of 2'-dG to 8-OH-2'-dG induced by Fe(3+)-EDTA/H2O2/ascorbic acid. Gallic acid had a prooxidant effect, but trolox and mannitol had an antioxidant effect. The leaf extract had a marked inhibitory effect on Fenton reaction induced oxidative damage in biomolecules. The extract of roasted cortex exhibited modest inhibition while the extract of raw cortex had the least inhibitory effect on oxidative damage in biomolecules. This is in contrast to gallic acid in the same reaction system, whose higher reducing power and weaker chelating ability may contribute to its prooxidant effect. In the present study, leaf extract of Du-zhong had inhibitory effect on oxidative damage in biomolecules. Therefore, drinking of Du-zhong tea (leaf extract) over a long period of time may have anticancer potential.
机译：这项研究旨在研究杜仲水提取物对Fenton反应诱导的生物分子如脱氧核糖，DNA和2'-deoxyguanosine（2'-dG）氧化损伤的抗氧化作用。使用的WEDZ包括叶子，原始皮层和烤皮层。所有的WEDZ都以浓度依赖的方式抑制了Fe（3 +）-EDTA / H2O2 /抗坏血酸诱导的脱氧核糖的氧化。在1.14 mg / mL的浓度下，叶提取物，烤皮层和原始皮层的抑制作用分别为85.2％，68.0％和49.3％。叶子的提取物在5和10微克/微升的浓度下抑制了Fenton反应诱导的DNA链断裂。这种抑制作用类似于甘露醇，而原始皮层和烤皮层的提取物完全没有抑制作用。 WEDZ还抑制了由Fe（3 +）-EDTA / H2O2 /抗坏血酸诱导的2'-dG氧化为8-OH-2'-dG。没食子酸具有抗氧化作用，而trolox和甘露醇具有抗氧化作用。叶提取物对芬顿反应诱导的生物分子氧化损伤具有明显的抑制作用。烤皮层提取物表现出适度的抑制作用，而生皮层提取物对生物分子的氧化损伤抑制作用最小。这与相同反应体系中的没食子酸相反，没食子酸的较高还原能力和较弱的螯合能力可能有助于其促氧化作用。在本研究中，杜仲叶提取物对生物分子的氧化损伤具有抑制作用。因此，长时间饮用杜仲茶（叶提取物）可能具有抗癌潜力。

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