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首页> 外文期刊>Life sciences >Effects of time of day on chlorpyrifos-induced alterations in body temperature
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Effects of time of day on chlorpyrifos-induced alterations in body temperature

机译：一天中的时间对毒死rif引起的体温变化的影响

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Chlorpyrifos (CPF) is an organophosphate (OP) insecticide and is among the most common and widely used commercial insecticides. Human intoxication is reported to result in a typical set of responses, which include an immediate and long lasting hyperthermic response (fever). Rodents exposed to similar doses exhibit a biphasic body temperature response: short-term hypothermia followed by subtle hyperthermia several days after administration. Time of day of administration has been suggested to alter the body temperature effect of CPE In the present study, it is shown that adult male Sprague-Dawley rats exposed to CPF via (oral) gavage at four different times of the day demonstrate a hypothermic response, the timing and magnitude of which is independent of time of exposure and that is blocked by atropine pretreatment. However, a delayed (hyperthermic) response seems to be exhibited only when dosing occurs during the light phase. Our findings support existing theories that the hypothermic and hyperthermic effects of CPF work through independent mechanisms. It is also suggested that humans may indeed exhibit a biphasic temperature response to CPF intoxication, but that it is not typically detected. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 13]
机译：毒死rif（CPF）是一种有机磷酸盐（OP）杀虫剂，是最常见和使用最广泛的商业杀虫剂之一。据报道，人中毒会导致一系列典型的反应，包括立即和长期的高热反应（发烧）。暴露于相似剂量的啮齿动物表现出双相体温响应：给药后数天，短期体温过低，继而微妙的体温过高。已建议一天中的给药时间改变CPE对体温的影响。在本研究中，研究表明成年雄性Sprague-Dawley大鼠在一天中的四个不同时间通过（口服）强饲法暴露于CPF中，表现出低温反应，其时间和大小与接触时间无关，并且被阿托品预处理所阻断。但是，似乎仅在轻量阶段发生剂量分配时才表现出延迟的（高热）反应。我们的发现支持现有的理论，即CPF的低温和高温效应通过独立的机制起作用。还建议人类可能确实表现出对CPF中毒的双相温度反应，但通常无法检测到。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：13]

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