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Endogenous cannabinoids: Metabolism and their role in reproduction [Review]

机译：内源性大麻素：代谢及其在生殖中的作用[综述]

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摘要

Over the past two decades a number of endogenous compounds that act as ligands for the cannabinoid receptors has been discovered. In analogy with the "endorphins" these compounds have been called "endocannabinoids". Endocannabinoids have been demonstrated in many mammalian tissues including humans and are widely distributed in the CNS, peripheral nerves, uterus, leukocytes, spleen and testicles. The uterus contains the highest levels of anandamide, the first discovered endocannabinoid, suggesting an important role for this substance in reproduction. Several studies have shown anandamide to be involved in the regulation of implantation and reduced activity of the enzyme that degrades anandamide has been associated with early pregnancy loss in humans. The bulk of the literature concerning endocannabinoids is based upon anandamide related studies; therefore, in this review we focus on the metabolism of anandamide and its role in reproduction. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 103]
机译：在过去的二十年中，已发现许多内源性化合物，可作为大麻素受体的配体。与“内啡肽”类似，这些化合物被称为“内源大麻素”。内源性大麻素已在包括人类在内的许多哺乳动物组织中得到证实，并广泛分布于中枢神经系统，周围神经，子宫，白细胞，脾脏和睾丸中。子宫中含量最高的anandamide是最早发现的内源性大麻素，表明该物质在生殖中具有重要作用。几项研究表明，anandamide参与了植入的调控，而降解anandamide的酶活性降低与人类早期妊娠减少有关。有关内源性大麻素的大量文献是基于与阿南酰胺相关的研究。因此，在本综述中，我们着重研究Anandamide的代谢及其在生殖中的作用。 （C）2002 Elsevier Science Inc.保留所有权利。 [参考：103]

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