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首页> 外文期刊>Life sciences >Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line
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Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line

机译：芳香酵母（Szygium aromaum（L.）Merr。 Et Perry（桃金娘科）花芽诱导p815肥大细胞瘤细胞系凋亡

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This study was conducted to investigate SAFE-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFE induced many apoptotic manifestations as evidenced by changes in cell morphology, generation of DNA fragmentation, activation of caspase 3, and DNA hypoploidy. The reduction of mitochondrial membrane potential and the release of cytochrome c to cytosol were also demonstrated. However, reduction of mitochondrial membrane potential and cytochrome c release were not prevented by caspase inhibitor zVAD-fmk or PTP blockers such as bongkrekic acid and cyclosporin A. Expression levels of Bcl-2 and Fas remained unchanged following SAFE treatment. This results suggest that the clinical effect of SAFE may depend on the pharmacological mechanism regulating the demise of mast cells. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 33]
机译：进行这项研究是为了研究SAFE诱导的肥大细胞凋亡，因为它既涉及其基本药物机制，也涉及肥大细胞增殖所伴随的病理状况的潜在治疗方法。 SAFE诱导了许多凋亡表现，如细胞形态的变化，DNA片段的产生，caspase 3的激活和DNA次倍性所证明。还证实了线粒体膜电位的降低和细胞色素c向细胞质的释放。但是，caspase抑制剂zVAD-fmk或PTP阻滞剂（如邦克里基酸和环孢菌素A）并未阻止线粒体膜电位的降低和细胞色素c的释放。SAFE处理后Bcl-2和Fas的表达水平保持不变。该结果表明，SAFE的临床效果可能取决于调节肥大细胞死亡的药理机制。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：33]

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