Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells.

Takane H; Ohdo S; Yamada T; Koyanagi S; Yukawa E; Higuchi S

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Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells.

机译：植入肿瘤细胞的细胞周期昼夜节律与干扰素受体表达之间的关系。

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Whether the diurnal rhythm of cell cycle is associated with that of interferon-alpha/beta receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-alpha to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-beta. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

机译：在植入的肿瘤细胞中研究了细胞周期的昼夜节律是否与干扰素-α/β受体（IFNAR）的表达有关。当肿瘤细胞在DNA合成（S）阶段的比例在体外增加时，IFNAR mRNA的表达显着增加。在植入的肿瘤细胞中观察到昼夜节律的细胞周期分布。当体内S期肿瘤细胞的比例增加时，干扰素-α与受体和IFNAR mRNA的特异性结合增加。 IFNAR的时间依赖性表达受干扰素-β诱导的转录因子水平的支持。目前的结果表明，IFNAR表达的节奏与植入肿瘤细胞中细胞周期分布的节奏密切相关。

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来源
《Life sciences》 |2001年第12期|共7页
作者
Takane H; Ohdo S; Yamada T; Koyanagi S; Yukawa E; Higuchi S;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Cell Cycle; Circadian Rhythm; Melanoma; Receptors; Interferon; Interferon-alpha; 细胞周期; 昼夜节律; 黑色素瘤; 受体; 干扰素;

机译：Cell Cycle;Circadian Rhythm;Melanoma;Receptors;Interferon;Interferon-alpha;细胞周期;昼夜节律;黑色素瘤;受体;干扰素;

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1. Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells. [J] . Takane H, Ohdo S, Yamada T, Life sciences . 2001,第12期

机译：植入肿瘤细胞的细胞周期昼夜节律与干扰素受体表达之间的关系。
2. Lenalidomide down regulates the production of interferon-gamma and the expression of inhibitory cytotoxic receptors of human Natural Killer cells. [J] . Dauguet N, Fournie JJ, Poupot R, Cellular immunology . 2010,第2期

机译：来那度胺下调人天然杀伤细胞的干扰素-γ的产生和抑制性细胞毒性受体的表达。
3. Expression of mRNA for 55-kDa and 75-kDa tumor necrosis factor (TNF) receptors in mouse cerebrovascular endothelium: effects of interleukin-1 beta, interferon-gamma and TNF-alpha on cultured cells. [J] . Bebo BF Jr, Linthicum DS Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1995,第2期

机译：小鼠脑血管内皮中55-kDa和75-kDa肿瘤坏死因子（TNF）受体的mRNA表达：白介素1β，干扰素-γ和TNF-α对培养细胞的影响。
4. A T1D-associated lncRNA modulates the type I interferon signaling and the antiviral response in pancreatic beta cells. [C] . Itziar Gonzalez-Moro, Izortze Santin IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：T1D相关的LNCRNA调节I型干扰素信号传导和胰腺β细胞中的抗病毒反应。
5. Transfer and expression of a retrovirus vector containing an interferon-alpha1 gene in interferon deficient cultured cells. [D] . Dilling, Michael Bruce. 1993

机译：含有干扰素-α1基因的逆转录病毒载体在干扰素缺乏的培养细胞中的转移和表达。
6. Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells. [O] . K Kameyama, S Tanaka, Y Ishida, 1989

机译：干扰素调节鼠黑色素瘤细胞表面激素受体的表达。
7. Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells. [O] . Kameyama, K, Tanaka, S, Ishida, Y, 1989

机译：干扰素调节鼠黑色素瘤细胞表面激素受体的表达。

Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells.

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