• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward.
【24h】

Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward.

机译：伏打内cAMP特异性磷酸二酯酶抑制剂，咯利普兰和可卡因输注对大脑刺激的加成作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Evidence from cocaine self-administration studies suggests that increasing the activity of cyclic AMP (cAMP) pathways within the nucleus accumbens may produce a reduction in cocaine's reinforcing effects. Rolipram may increase intra-cellular levels of cAMP by selectively inhibiting Type IV phosphodiesterases, enzymes that catalyze cAMP breakdown. The present study was undertaken to test the hypothesis that infusion of rolipram into the nucleus accumbens would decrease cocaine-induced enhancement of the sensitivity of brain stimulation reward (BSR) pathways. BSR thresholds were determined in rats after the systemic administration of cocaine (4 mg/kg IP) and the infusion of rolipram (0.2 microg/side) into the nucleus accumbens both alone and in combination. Thresholds also were determined after the systemic administration of rolipram alone and, as a positive control, for amphetamine (10 microg/side) infused into the nucleus accumbens. BSR thresholds were significantly lowered below baseline levels following d-amphetamine administration suggesting that cannulae were in place to allow perfusion of reward pathways. Compared to values for saline alone, thresholds were lower after the injection of cocaine (4 mg/kg IP) or the infusion of rolipram (0.2 microg/side) into the nucleus accumbens. Treatment with the combination of cocaine and intra-nucleus accumbens rolipram produced a greater lowering of the BSR threshold than did administration of either rolipram or cocaine alone. Systemic administration of rolipram (0.5 mg/kg IP) either blocked the effects of BSR or raised BSR thresholds and produced stimulation-induced head jerking in most of the test animals. These results suggest that infusion into the nucleus accumbens of rolipram, an agent that putatively elevates cAMP levels in this structure, can enhance the sensitivity of reward pathways to BSR and can augment cocaine's actions on these pathways.
机译：可卡因自我管理研究的证据表明，增加伏伏核内循环AMP（cAMP）通路的活性可能会降低可卡因的增强作用。咯利普兰可能通过选择性抑制IV型磷酸二酯酶（催化cAMP分解的酶）来提高细胞内cAMP的水平。进行本研究以检验以下假设：将伏利普兰输注到伏隔核中会减少可卡因诱导的脑刺激奖励（BSR）途径敏感性的增强。在全身性施用可卡因（4 mg / kg腹膜内注射）并分别将伏立普仑（0.2微克/侧）输注伏隔核后，确定大鼠的BSR阈值。单独全身性服用咯利普兰后，以及作为阳性对照的安非他明（10微克/侧）注入伏隔核中，也要确定阈值。 d-苯异丙胺给药后，BSR阈值显着降低至基线水平以下，表明存在插管以允许灌注奖励途径。与单独使用生理盐水的值相比，注射可卡因（4 mg / kg IP）或将伏立普兰（0.2 microg /侧）注入伏隔核后的阈值较低。与单独使用咯利普兰或可卡因相比，用可卡因和伏隔核内组合来利普兰治疗可使BSR阈值降低更大。咯利普兰（0.5 mg / kg IP）的全身性给药阻断了BSR的作用或提高了BSR阈值，并在大多数试验动物中引起了刺激引起的头部抽搐。这些结果表明，往来普利普核中的输注可以有效提高该结构中cAMP的水平，从而可以提高奖励途径对BSR的敏感性，并增强可卡因在这些途径上的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号