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首页> 外文期刊>Life sciences >GINSENOSIDES OF THE PROTOPANAXATRIOL GROUP CAUSE ENDOTHELIUM-DEPENDENT RELAXATION IN THE RAT AORTA
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GINSENOSIDES OF THE PROTOPANAXATRIOL GROUP CAUSE ENDOTHELIUM-DEPENDENT RELAXATION IN THE RAT AORTA

机译：原戊三醇基的人参皂甙可引起大鼠主动脉内皮依赖性舒张

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摘要

The vasoactive effects of several ginsenosides, purified from Panax ginseng, were tested in the rat aorta. Ginsenosides from the protopanaxatriol group and its purified ginsenosides Rg(1) and Re cause endothelium dependent relaxation which is associated with the formation of cyclic GMP. Both responses to these protopanaxatriol-containing ginsenosides are inhibited by methylene blue, an inhibitor of soluble guanylate cyclase and of nitric oxide synthase. In contrast, ginsenosides from the protopanaxadiol group and its purified ginsenosides Rb, and Re do not affect vascular tone or production of cyclic GMP in the rat aorta. These findings demonstrate that ginsenosides from the protopanaxatriol group but not from the protopanaxadiol group enhance the release of nitric oxide from endothelial cells and may contribute to the beneficial effect of ginseng on the cardiovascular system. [References: 11]
机译：在大鼠主动脉中测试了从人参提取的几种人参皂苷的血管活性作用。人参皂苷原protopanaxatriol组及其纯化的人参皂苷Rg（1）和Re导致内皮依赖性舒张，这与环状GMP的形成有关。对这些含有前托泊三醇的人参皂苷的两种反应均被亚甲基蓝抑制，亚甲基蓝是可溶性鸟苷酸环化酶和一氧化氮合酶的抑制剂。相反，原人参二醇组的人参皂苷及其纯化的人参皂苷Rb和Re不会影响大鼠主动脉的血管紧张度或环状GMP的产生。这些发现表明，原人参三醇组的人参皂苷而不是原人参二醇组的人参皂苷增强了内皮细胞中一氧化氮的释放，可能有助于人参对心血管系统的有益作用。 [参考：11]

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