首页> 外文期刊>Life sciences >COMPARISON OF CHROMOGRANIN A AND PANCREASTATIN LEVELS IN PLASMA OF PATIENTS WITH PANCREATIC ISLET CELL TUMOR
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COMPARISON OF CHROMOGRANIN A AND PANCREASTATIN LEVELS IN PLASMA OF PATIENTS WITH PANCREATIC ISLET CELL TUMOR

机译:胰岛细胞肿瘤患者血浆嗜铬蛋白A和胰抑素水平的比较。

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The plasma levels of chromogranin A (CGA) in patients with islet cell tumor and plasma CGA responses to administration of a somatostatin analogue (Octreotide) in two of these patients were examined in comparison with plasma pancreastatin (PST) levels. There was a significant correlation between the fasting plasma levels of CGA and PST (r=0.6, P<0.001). Administration of the somatostatin analogue reduced the plasma concentrations of PST and CGA within 1 h, but the responses of CGA and PST to the analogue were not parallel in either patient. Thus, the suppressive effects of the analogue on the secretions of PST and CGA may be different. The results suggest the value of the PST and CGA assays used in this study. [References: 18]
机译:在胰岛细胞瘤患者中,嗜铬粒蛋白A(CGA)的血浆水平以及其中两名患者对血浆生长激素抑制素类似物(奥曲肽)的血浆CGA反应进行了比较,并与血浆胰酶抑素(PST)水平进行了比较。空腹血浆CGA与PST之间存在显着相关性(r = 0.6,P <0.001)。生长抑素类似物的给药在1 h内降低了PST和CGA的血浆浓度,但CGA和PST对类似物的反应在任一患者中均不平行。因此,类似物对PST和CGA的分泌的抑制作用可能不同。结果表明本研究中使用的PST和CGA分析的价值。 [参考:18]

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