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THE RENIN ANGIOTENSIN SYSTEM AND NOCICEPTION IN SPONTANEOUSLY HYPERTENSIVE RATS

机译:自发性高血压大鼠的肾素血管紧张素系统和镇静

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This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril (95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change. [References: 16]
机译:这项研究调查了卡托普利,肼苯哒嗪和氯沙坦对自发性高血压大鼠(SHR)及其遗传控制Wistar-Kyoto大鼠(WKY)的运动活性,甩尾和热板潜伏期的影响。卡托普利(95 mg / kg / day po)和氯沙坦(18 mg / kg / day po)处理可正常减轻自发性高血压大鼠通常表现出的热板潜伏期增加或消失,但不受肼苯哒嗪(19 mg / kg)的影响/天po)。没有任何药物对甩尾潜伏期或运动活动有明显影响。结果强调了血管紧张素II在镇痛中的潜在作用,而与血压变化无关。 [参考:16]

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