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CHRONIC EXERCISE ENHANCES ENDOTHELIUM-MEDIATED DILATION IN SPONTANEOUSLY HYPERTENSIVE RATS

机译：慢性运动可增强自发性高血压大鼠内皮细胞介导的稀释作用

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This study investigated the effect of physical training on endothelial function in spontaneously hypertensive rats (SHR). After 3 months, in conscious trained- and untrained-SHR body weight, systolic blood pressure and heart rate were 220+/-5 g vs. 271+/-9 g, 172+/-7 mmHg vs. 210+/-8 mmHg and 314+/-10 vs. 348+/-12 beats/min, respectively. In vitro, the dose-response curves of norepinephrine in isolated intact aortic and mesenteric rings from the exercise trained-SHR were significantly lower than those from the untrained-SHR. With denuded preparations, norepinephrine concentration-response curves were shifted to the left both in the trained- and untrained-SHR. This shift in the trained-SHR exceeded that in the untrained-SHR. The vasodilator response to acetylcholine in the trained-SHR was significantly greater than that in the untrained-SI-IX, Either N-omega-nitro-L-arginine (100 mu mol/l) or methylene blue (10 mu mol/l) inhibited acetylcholine-induced vasodilator effect in aorta of trained- and untrained-SHR, but not in mesenteric artery of trained-SHR. Tetraethylammonium (10 mmol/l) inhibited significantly the N-omega-nitro-L-arginine and methylene blue-resistant relaxation in mesenteric artery of trained-SHR, but not by indomethacin (10 mu mol/l). Collectively, these data demonstrate that chronic exercise increases EDRF/EDHF production (presumably by increasing endothelial shear stress), and may contribute to the enhanced effects of post-exercise hypotension.(1) [References: 40]
机译：这项研究调查了体育锻炼对自发性高血压大鼠（SHR）内皮功能的影响。 3个月后，在有意识的经过训练和未经训练的SHR体重中，收缩压和心率分别为220 +/- 5 g和271 +/- 9 g，172 +/- 7 mmHg和210 +/- 8 mmHg和314 +/- 10 vs.348 +/- 12次/分钟。在体外，运动训练的SHR分离的完整主动脉和肠系膜环中去甲肾上腺素的剂量反应曲线显着低于未训练的SHR。对于裸露的制剂，在训练和未训练的SHR中，去甲肾上腺素的浓度-反应曲线都向左移动。训练有素的SHR的这种变化超过了未训练的SHR的变化。在训练有素的SHR中，对乙酰胆碱的血管舒张反应明显大于未训练的SI-IX，N-ω-硝基-L-精氨酸（100μmol / l）或亚甲基蓝（10μmol / l）。抑制乙酰胆碱诱导的受过训练和未受过训练的SHR的主动脉血管舒张作用，但对受过训练的SHR的肠系膜动脉没有抑制作用。四乙基铵（10 mmol / l）可以显着抑制受过训练的SHR的肠系膜动脉的N-ω-硝基-L-精氨酸和耐亚甲基蓝的松弛作用，但不会抑制吲哚美辛（10μmol/ l）的作用。总的来说，这些数据表明，长期运动会增加EDRF / EDHF的产生（大概是通过增加内皮切应力），并且可能有助于增强运动后低血压的作用。（1）[参考：40]

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