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首页> 外文期刊>Life sciences >The awakening cortisol response: no evidence for an influence of body posture.
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The awakening cortisol response: no evidence for an influence of body posture.

机译：觉醒的皮质醇反应：没有证据表明身体姿势会受到影响。

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It has recently been reported that the orthostatic challenge associated with postural change from sitting to an upright position is stimulatory to the hypothalamic-pituitary-adrenal axis as evidenced by increased salivary free cortisol. This stimulatory influence is potentially a confound for the many psychoneuroendocrine studies for which salivary free cortisol is the main dependent variable. This particularly relates to laboratory psychosocial stress procedures in which subjects are invited to stand in order to deliver public speech and the studies which have explored the cortisol response to awakening in which postural shift has not been controlled for. We therefore examined, in a balanced cross over design whether the awakening cortisol response was influenced by standing, shortly after awakening or remaining supine during the response study period. In addition and in the same subjects we measured the cardiovascular response and saliva cortisol response to the orthostatic challenge of shifting from a supine to a standing position later in the diurnal cortisol cycle. The expected cortisol response to awakening was demonstrated but there was no evidence that the postural shift, supine to standing, confounded the response. This same postural shift later in the day induced the expected increase in heart rate but cortisol simply followed the circadian decline. Under the conditions of the present study we found no evidence that the postural shift supine to standing could induce a cortisol secretory episode such as to contribute towards the awakening response.
机译：最近有报道称，与体位从坐姿改变到直立姿势有关的体位性挑战对下丘脑-垂体-肾上腺轴有刺激作用，唾液游离皮质醇的增加证明了这一点。对于许多神经神经内分泌研究来说，这种刺激性影响可能是混淆的，在这些研究中唾液游离皮质醇是主要的因变量。这尤其涉及实验室的心理社会压力程序，在该程序中邀请受试者站立以发表公开演讲，以及涉及探索皮质醇对觉醒的反应的研究，在这些研究中，体位变化并未得到控制。因此，我们在平衡的交叉设计中检查了唤醒皮质醇的反应是否受到反应研究期间站立，唤醒后不久或保持仰卧的影响。另外，在同一受试者中，我们测量了在昼夜皮质醇循环中从仰卧位转为站立姿势的体位性挑战的心血管反应和唾液皮质醇反应。证实了预期的皮质醇对觉醒的反应，但是没有证据表明从仰卧到站立的姿势改变会混淆反应。当天晚些时候，同样的姿势变化导致预期的心率增加，但皮质醇仅跟随昼夜节律下降。在本研究的条件下，我们没有发现证据表明仰卧姿势向站立姿势转变可以诱导皮质醇分泌发作，从而有助于唤醒反应。

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