• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Melatonin reverses neurochemical alterations induced by 6-OHDA in rat striatum.
【24h】

Melatonin reverses neurochemical alterations induced by 6-OHDA in rat striatum.

机译：褪黑素逆转了大鼠纹状体中6-OHDA诱导的神经化学改变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present work showed that the intrastriatal injection of 6-OHDA significantly decreases DA, DOPAC and HVA levels in that rat brain structure. Although there is also a decrease in 5-HT levels no changes were observed in 5-HIAA levels as compared to controls. On the other hand, melatonin (2, 5, 10 and 25 mg/kg. i.p., daily for 7 days) treatment starting 1 h after 6-OHDA lesions, partially reverses the decreases caused by 6-OHDA lesions on these neurotransmitter levels, and contents were brought to approximately 50% of that observed in the contralateral sides of controls or of melatonin treated group. Melatonin was more efficient at the doses of 5 and 10 mg/kg, i.p., and effects were similar between the lowest and highest doses characteristic of a bell-shaped type of response. The apomorphine-induced rotational behavior (3 mg/kg, i.p.) was blocked by 60, 89, 78 and 47% after the doses of 2, 5, 10 and 25 mg/kg, i.p., respectively. Similarly, in this case the doses of 5 and 10 mg/kg were also more efficient. Melatonin (5 mg/kg) produced an upregulation of D1 receptors associated with a decrease in Kd value. While no change was observed in maximum density of D2 receptors, the Kd value was also decreased.
机译：目前的研究表明，纹状体内注射6-OHDA可以显着降低该大鼠脑结构中的DA，DOPAC和HVA水平。尽管5-HT水平也降低，但与对照相比5-HIAA水平未见变化。另一方面，褪黑激素（2、5、10和25 mg / kg ip，每天ip，连续7天）在6-OHDA损伤后1小时开始治疗，部分逆转了这些神经递质水平上由6-OHDA损伤引起的减少，并且其含量约为对照组或褪黑激素治疗组对侧的50％。褪黑激素在5和10 mg / kg腹膜内给药时更有效，并且在钟形反应类型的最低和最高剂量之间效果相似。在分别以2、5、10和25 mg / kg的剂量注射后，阿扑吗啡诱导的旋转行为（3 mg / kg，腹腔注射）被60％，89、78和47％阻断。同样，在这种情况下，5和10 mg / kg的剂量也更有效。褪黑激素（5 mg / kg）产生了与Kd值降低相关的D1受体上调。虽然未观察到D2受体的最大密度的变化，但Kd值也降低了。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号