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首页> 外文期刊>Cell biology international. >Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells
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Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells

机译：五味子的七种二苯并环辛二烯木脂素对SH-SY5Y细胞血清和葡萄糖剥夺的保护作用

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摘要

Dibenzocyclooctadiene lignans, the major active components of fruit of Schisandra chinensis (Turcz.) Baill., have been found to have activities that could prevent prostate and thyroid cancer, hepatotoxicity, oxidative stress-induced cerebral injury, etc. This study was conducted to evaluate the effects of seven dibenzocyclooctadiene lignans of Schisandra chinensis and explore the possible mechanisms in the human neuroblastoma SH-SY5Y cells exposed on serum and glucose deprivation (SGD) injury. The structure-activity relationships were also analyzed. Cell viability and lactate dehydrogenase (LDH) release were determined to evaluate cell injury. Inflammation and apoptosis-related protein levels were detected to elucidate the possible mechanisms. Schisantherin A, schizandrin C, and schizandrol B were found to have stronger protective effects than schizandrin A, schizandrin B, and schisanhenol in SH-SY5Y cells against SGD injury. Moreover, the protective effects of these lignans were possibly exhibited by regulating inflammation and apoptosis-related proteins in SH-SY5Y cells after SGD injury, supporting their beneficial effects for the prevention of cell injury in the pathogenesis of the central nervous system diseases, including ischemia stroke. The number and position of hydroxyl group and methylenedioxy in these lignans may be required for their effects.
机译：已发现五味子果实中的主要活性成分二苯并环辛二烯木脂素具有可以预防前列腺癌和甲状腺癌，肝毒性，氧化应激引起的脑损伤等活性。本研究旨在评估研究七味五味子的二苯并环辛二烯木脂素的作用，并探讨暴露于血清和葡萄糖剥夺（SGD）损伤的人神经母细胞瘤SH-SY5Y细胞的可能机制。构效关系也进行了分析。确定细胞活力和乳酸脱氢酶（LDH）释放以评估细胞损伤。检测炎症和凋亡相关蛋白水平以阐明可能的机制。发现五味子素A，五味子素C和五味子醇B在SH-SY5Y细胞中对SGD损伤具有比五味子素A，五味子素B和五味子酚更强的保护作用。此外，这些木脂素的保护作用可能通过调节SGD损伤后SH-SY5Y细胞中的炎症和凋亡相关蛋白而发挥作用，支持它们在预防中枢神经系统疾病（包括局部缺血）的发病中对细胞损伤的有益作用。中风。这些木脂素中的羟基和亚甲二氧基的数量和位置可能需要它们的作用。

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