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首页> 外文期刊>Cell biology international. >Transdifferentiation of chondrocytes into neuron-like cells induced by neuronal lineage specifying growth factors
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Transdifferentiation of chondrocytes into neuron-like cells induced by neuronal lineage specifying growth factors

机译：由神经元谱系诱导的软骨细胞向神经元样细胞的转分化，指明了生长因子

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We previously reported that neural-crest-derived stromal cells from adult human and rat corneas can differentiate into neuron-like cells when treated with neuronal lineage specifying growth factors. However, it remains unclear whether this level of cell plasticity is unique to the corneal stromal cell population present in the eye. In this study, non-neural-crest-derived chondrocytes from the xiphosternum of adult rats were subjected to the same differentiation protocol. Cells of the adult rat xiphosternum can also differentiate into neuron-like cells when treated with neurogenic differentiation specifying growth factors. After 1 week in neurogenic differentiation culture conditions, the chondrocytes changed from a round to a stellate morphology and started to express neuron-specific protein neurofilament-200 (NF-200), microtubule associated protein-2 (Map-2), and -III tubulin. Lineage-specifying growth factors can affect changes in morphology and protein expression of adult cells in culture, findings that challenge the notion of a restricted differentiation potential of adult cell populations and questions the stability of the differentiated state of cells.
机译：我们以前曾报道过，当用指定生长因子的神经元谱系处理时，来自成年人类和大鼠角膜的神经基质细胞可以分化为神经元样细胞。然而，尚不清楚这种水平的细胞可塑性是否为眼睛中存在的角膜基质细胞群所独有。在这项研究中，成年大鼠剑突的非神经c来源的软骨细胞接受相同的分化方案。成年大鼠剑鞘的细胞在用指定生长因子的神经原性分化处理时也可以分化为神经元样细胞。在神经原性分化培养条件下1周后，软骨细胞从圆形变为星状，并开始表达神经元特异性蛋白Neurofilament-200（NF-200），微管相关蛋白2（Map-2）和-III。微管蛋白。特定于世系的生长因子会影响培养物中成年细胞的形态和蛋白质表达的变化，这一发现挑战了成年细胞群体有限的分化潜能，并质疑细胞分化状态的稳定性。

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