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Deoxyribozymes and bioinformatics: Complementary tools to investigate axon regeneration

机译：脱氧核酶和生物信息学：研究轴突再生的辅助工具

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For over 100 years, scientists have tried to understand the mechanisms that lead to the axonal growth seen during development or the lack thereof during regeneration failure after spinal cord injury (SCI). Deoxyribozyme technology as a potential therapeutic to treat SCIs or other insults to the brain, combined with a bioinformatics approach to comprehend the complex protein-protein interactions that occur after such trauma, is the focus of this review. The reader will be provided with information on the selection process of deoxyribozymes and their catalytic sequences, on the mechanism of target digestion, on modifications, on cellular uptake and on therapeutic applications and deoxyribozymes are compared with ribozymes, siRNAs and antisense technology. This gives the reader the necessary knowledge to decide which technology is adequate for the problem at hand and to design a relevant agent. Bioinformatics helps to identify not only key players in the complex processes that occur after SCI but also novel or less-well investigated molecules against which new knockdown agents can be generated. These two tools used synergistically should facilitate the pursuit of a treatment for insults to the central nervous system.
机译：一百多年来，科学家一直试图了解导致发育过程中轴突生长或脊髓损伤（SCI）后再生失败时缺乏轴突生长的机制。脱氧核酶技术作为治疗SCI或其他对大脑的侮辱的潜在疗法，结合生物信息学方法来理解此类创伤后发生的复杂蛋白质间相互作用，是本综述的重点。将为读者提供有关脱氧核酶的选择过程及其催化序列，靶标消化机制，修饰，细胞摄取和治疗用途的信息，并将脱氧核酶与核酶，siRNA和反义技术进行比较。这为读者提供了必要的知识，以决定哪种技术适合当前的问题并设计相关的代理商。生物信息学不仅可以帮助确定SCI之后发生的复杂过程的关键参与者，而且还可以帮助研究出新颖的或研究较少的分子，从而可以针对这些分子产生新的基因敲除剂。协同使用的这两种工具应有助于对中枢神经系统的损伤进行治疗。

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