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首页> 外文期刊>Cell and Tissue Research >High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer.
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High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer.

机译：产生IL-17的细胞的高密度与晚期上皮性卵巢癌的预后改善有关。

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Interleukin (IL)-17 is the signature cytokine of T helper 17 cells. The role of IL-17 in the tumor microenvironment is still controversial. Few studies describing IL-17 expression in ovarian cancer have been reported. We have therefore analyzed the in situ tumor expression of IL-17 in advanced ovarian cancer and the possible correlation of IL-17 expression with tumor-associated macrophages (TAMs) and with survival in advanced ovarian cancer. Clinical data of 104 patients with stage III-IV epithelial ovarian cancer at the Sun Yat-sen University Cancer Center between 2000 and 2008 were retrospectively reviewed. Immunohistochemical staining of IL-17 and CD163 (marker for TAMs) was performed. Our data showed that levels of IL-17 were significantly increased in ovarian cancer compared with normal ovarian tissues (P<0.001). The high IL-17 expression group included more patients with grade 1 tumors than the low IL-17 expression group (P=0.042). High IL-17 expression correlated with improved progression-free survival (PFS) in advanced ovarian cancer (P<0.001). However, no significant difference was observed in overall survival between the high and low IL-17 expression groups. Multivariate analysis revealed that the density of IL-17-producing cells was a positive prognostic factor for PFS (P=0.001). Moreover, a positive correlation between the density of IL-17-producing cells and TAMs was identified (r=0.354, P<0.001). Our results indicate that the infiltration of IL-17-producing cells might contribute to improved PFS in advanced ovarian cancer. Our findings provide a new insight into the complex role of IL-17 in the tumor microenvironment of ovarian cancer.
机译：白介素（IL）-17是T辅助17细胞的标志性细胞因子。 IL-17在肿瘤微环境中的作用仍存在争议。很少有报道描述IL-17在卵巢癌中的表达。因此，我们已经分析了晚期卵巢癌中IL-17的原位肿瘤表达以及IL-17表达与肿瘤相关巨噬细胞（TAM）以及晚期卵巢癌生存率的可能相关性。回顾性分析了中山大学肿瘤防治中心2000年至2008年间104例III-IV期上皮性卵巢癌患者的临床资料。进行了IL-17和CD163（TAMs的标记）的免疫组织化学染色。我们的数据显示，与正常卵巢组织相比，卵巢癌中IL-17的水平显着增加（P <0.001）。高IL-17表达组比低IL-17表达组包括更多的1级肿瘤患者（P = 0.042）。 IL-17的高表达与晚期卵巢癌的无进展生存期（PFS）改善相关（P <0.001）。但是，在高和低IL-17表达组之间的总生存期中未观察到显着差异。多变量分析显示，产生IL-17的细胞密度是PFS的阳性预后因素（P = 0.001）。此外，鉴定出IL-17产生细胞的密度与TAM之间的正相关（r ＝ 0.354，P ＜0.001）。我们的结果表明，IL-17产生细胞的浸润可能有助于改善晚期卵巢癌中的PFS。我们的发现为IL-17在卵巢癌肿瘤微环境中的复杂作用提供了新的见解。

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