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首页> 外文期刊>Cell and Tissue Research >NO/cGMP signalling: L: -citrulline and cGMP immunostaining in the central complex of the desert locust Schistocerca gregaria.
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NO/cGMP signalling: L: -citrulline and cGMP immunostaining in the central complex of the desert locust Schistocerca gregaria.

机译：NO / cGMP信号传导：L：-瓜氨酸和cGMP免疫染色在沙漠蝗虫日本血吸虫的中央复合体中。

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摘要

Nitric oxide (NO) is a gaseous messenger molecule formed during conversion of L: -arginine into L: -citrulline by the enzyme NO synthase (NOS), which belongs to a group of NADPH diaphorases. Because of its gaseous diffusion properties, NO differs from classical neurotransmitters in that it is not restricted to synaptic terminals. In target cells, NO activates soluble guanylyl cyclase leading to an increase in cGMP levels. In insects, this NO/cGMP-signalling pathway is involved in development, memory formation and processing of visual, olfactory and mechanosensory information. We have analysed the distribution of putative NO donor and target cells in the central complex, a brain area involved in sky-compass orientation, of the locust Schistocerca gregaria by immunostaining for L: -citrulline and cGMP. Six types of citrulline-immunostained neurons have been identified including a bilateral pair of hitherto undescribed neurons that connect the lateral accessory lobes with areas anterior to the medial lobes of the mushroom bodies. Three-dimensional reconstructions have revealed the connectivity pattern of a set of 18 immunostained pontine neurons of the central body. All these neurons appear to be a subset of previously mapped NADPH-diaphorase-positive neurons of the central complex. At least three types of central-complex neurons show cGMP immunostaining including a system of novel columnar neurons connecting the upper division of the central body and the lateral triangle of the lateral accessory lobe. Our results provide the morphological basis for further studies of the function of the labelled neurons and new insights into NO/cGMP signalling.
机译：一氧化氮（NO）是一种气态信使分子，它是通过NO合酶（NOS）转化L：-精氨酸为L：-瓜氨酸的过程中形成的，NOS合酶属于一组NADPH心肌黄递酶。由于其气体扩散特性，NO与经典的神经递质不同，因为它不限于突触末端。在靶细胞中，NO激活可溶性鸟嘌呤环化酶，导致cGMP水平升高。在昆虫中，这种NO / cGMP信号传递途径涉及视觉，嗅觉和机械感官信息的发育，记忆形成和处理。我们通过对L：-瓜氨酸和cGMP进行免疫染色，分析了蝗虫血吸虫中央中央复合体（参与天空罗盘定向的大脑区域）中假定的NO供体和靶细胞的分布。已经鉴定出六种瓜氨酸免疫染色的神经元，包括迄今未描述的双侧神经元，它们将侧副叶与蘑菇体中叶前面的区域连接起来。三维重建揭示了一组18个免疫染色的桥脑神经元的连接模式。所有这些神经元似乎是中央复合体先前映射的NADPH-心肌黄素酶阳性神经元的子集。至少三种类型的中枢复杂神经元显示出cGMP免疫染色，包括连接中枢主体上部和侧副叶旁三角的新型柱状神经元系统。我们的结果为标记的神经元功能的进一步研究和NO / cGMP信号的新见解提供了形态学基础。

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