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首页> 外文期刊>Cell and Tissue Research >Endothelial transcytosis in health and disease.
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Endothelial transcytosis in health and disease.

机译：内皮细胞转胞吞作用在健康和疾病中。

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摘要

The visionaries predicted the existence of transcytosis in endothelial cells; the cell biologists deciphered its mechanisms and (in part) the molecules involved in the process; the cell pathologists unravelled the presence of defective transcytosis in some diseases. The optimistic perspective is that transcytosis, in general, and receptor-mediated transcytosis, in particular, will be greatly exploited in order to target drugs and genes to exclusive sites in and on endothelial cells (EC) or underlying cells. The current recognition that plasmalemmal vesicles (caveolae) are the vehicles involved in EC transcytosis has moved through various phases from initial considerations of caveolae as unmovable sessile non-functional plasmalemma invaginations to the present identification of a multitude of molecules and a crowd of functions associated with these ubiquitous structures of endothelial and epithelial cells. Further understanding of the molecular machinery that precisely guides caveolae through the cells so as to reach the target membrane (fission, docking, and fusion), to avoid lysosomes, or on the contrary, to reach the lysosomes, and discharge the cargo molecules will assist in the design of pathways that, by manipulating the physiological route of caveolae, will carry molecules of choice (drugs, genes) at controlled concentrations to precise destinations.
机译：有远见的人预测内皮细胞存在转胞作用。细胞生物学家破译了其机制以及（部分）参与该过程的分子;细胞病理学家揭示了某些疾病中转胞作用缺陷的存在。乐观的观点是，为了将药物和基因靶向内皮细胞（EC）或基础细胞内和细胞上的排他位点，通常将广泛利用转细胞作用，尤其是受体介导的转细胞作用。目前认识到质膜囊泡（caveolae）是参与EC转胞吞作用的媒介，从最初认为小窝不能固定的无功能非功能性血浆病的侵袭到目前鉴定出的许多分子和与之相关的功能群已经历了多个阶段这些普遍存在的内皮细胞和上皮细胞结构。进一步了解精确引导小孔穿过细胞以到达靶膜（裂变，对接和融合），避免溶酶体或相反地到达溶酶体并释放货物分子的分子机制将有助于通过控制小窝的生理学途径，将控制浓度的选择分子（药物，基因）携带到精确的目的地。

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