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首页> 外文期刊>Cell and Tissue Research >The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.
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The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.

机译：黄酮类胰蛋白酶减弱了结直肠癌的病理重塑，减少了暴露于致癌物1,2-二甲基肼的大鼠的肿瘤前病变的数量和严重程度。

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摘要

Phenolic compounds are naturally occurring, bioactive substances with marked antioxidant and anti-inflammatory potential. The flavonoid chrysin, found in high levels in honey bee propolis, inhibits the activity of enzymes involved in carcinogenesis. We have investigated the effect of chrysin on pre-neoplastic colorectal lesions (ACF, aberrant crypt foci) in a rat model of chemical carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Female Wistar rats weighing 137.2 ± 24.3 g received weekly one subcutaneous injection of DMH (20 mg/kg) for 10 weeks. The animals were divided into five groups each with seven animals: Group 1, 0.9% saline; Group 2, DMH+0.9% saline; Group 3, DMH+chrysin (10 mg/kg); Group 4, DMH+chrysin (100 mg/kg); Group 5, DMH+chrysin (200 mg/kg). Groups 2 and 3 showed a significant increase in ACF number, nucleolus organizer regions per enterocyte nucleus and nitriteitrate serum levels compared with Group 1. Groups 4 and 5 presented a significant reduction in all these parameters compared with Group 2. The levels of antioxidant minerals (copper, magnesium, selenium, zinc) and the number of enteroendocrine and mucin-producing cells were significantly reduced in Groups 2 and 3 but were similar in Groups 4 and 5 compared with Group 1. Chrysin, at 100 mg/kg and 200 mg/kg, was effective in attenuating pathological colorectal remodeling, reducing the number of pre-neoplastic lesions in rats exposed to DMH. Some of these effects might be attributable to the recovery of antioxidant mineral levels, a reduction in systemic nitrosative stress and an inhibition of the cellular proliferation induced by this flavonoid.
机译：酚类化合物是天然存在的生物活性物质，具有明显的抗氧化剂和抗炎潜力。在蜜蜂蜂胶中发现的黄酮类黄绿素含量高，可抑制与癌变有关的酶的活性。我们已经研究了菊花素在1,2-二甲基肼（DMH）诱导的化学致癌大鼠模型中对肿瘤前大肠病变（ACF，隐窝灶）的影响。体重为137.2±24.3 g的雌性Wistar大鼠每周接受一次皮下注射DMH（20 mg / kg），持续10周。将动物分为五组，每组七只动物：第1组，0.9％盐水;第2组，DMH + 0.9％盐水;第3组，DMH +胰蛋白酶（10 mg / kg）;第4组，DMH +胰蛋白酶（100 mg / kg）;第5组，DMH +胰蛋白酶（200 mg / kg）。与第1组相比，第2和第3组显示ACF数量，每个肠细胞核的核仁组织区和亚硝酸盐/硝酸盐血清水平显着增加。与第2组相比，第4和第5组所有这些参数均显着降低。第2组和第3组的矿物质（铜，镁，硒，锌）以及肠内分泌和粘蛋白产生细胞的数量均显着减少，但与第1组相比，第4组和第5组的相似。毫克/千克有效地减轻了病理性大肠的重塑，减少了暴露于DMH的大鼠的肿瘤前病变的数量。这些影响中的一些可能归因于抗氧化剂矿物质水平的恢复，系统亚硝化应激的降低以及该类黄酮诱导的细胞增殖的抑制。

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