Septin9 is involved in T-cell development and CD8+ T-cell homeostasis

LassenL.B.; FüchtbauerA.; SchmitzA.; S?rensenA.B.; PedersenF.S.; FüchtbauerE.-M.

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Septin9 is involved in T-cell development and CD8+ T-cell homeostasis

机译：Septin9参与T细胞发展和CD8 + T细胞稳态

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SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8 + T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8+ central memory T-cells.

机译：SEPTIN9（SEPT9）是一种参与许多细胞过程的长丝形成蛋白。我们已使用Sept9的条件敲除等位基因来特异性删除T细胞中的Sept9。如荧光激活的细胞分选所示，在胸腺胸腺细胞早期阶段Sept9的缺失导致双阴性细胞数量增加，表明SEPT9参与了T细胞发育过程中从双阴性阶段的转变。因此，在具有Sept9的T细胞特异性缺失的小鼠中，外周成熟T细胞的相对数目减少。在培养中刺激后，脾脏中Sept9缺失的CD8 + T细胞的增殖减少。由Sept9缺失引起的T细胞稳态改变导致CD8 +中枢记忆T细胞增加。

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《Cell and Tissue Research》 |2013年第3期|共11页
作者
LassenL.B.; FüchtbauerA.; SchmitzA.; S?rensenA.B.; PedersenF.S.; FüchtbauerE.-M.;
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正文语种 eng
中图分类细胞生物学;
关键词
CD8+ T-cells; Mice (Sept9 cond:Mx-Cre); Sept9; T-cell development; T-cell homeostasis; T-cell proliferation;

机译：CD8 + T细胞;小鼠（Sept9 cond：Mx-Cre）;Sept9;T细胞发育;T细胞稳态;T细胞增殖;

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专利

1. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis [J] . LassenL.B., FüchtbauerA., SchmitzA., Cell and Tissue Research . 2013,第3期

机译：Septin9参与T细胞发展和CD8 + T细胞稳态
2. Differential requirements of CD4+ T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8+ T-cell precursor frequency [J] . UmeshappaC.S., NanjundappaR.H., XieY., Immunology: An Official Journal of the British Society for Immunology . 2013,第4期

机译：在较高的CD8 + T细胞前体频率下，效应细胞毒性T淋巴细胞（CTL）引发和功能性记忆CTL发育所需的CD4 + T细胞信号的差异要求
3. Absolute Requirement of Macrophages for the Development and Activation of β-Cell Cytotoxic CD8+ T-Cells in T-Cell Receptor Transgenic NOD Mice [J] . Hee-Sook Jun, Pere Santamaria, Hye-Won Lim Diabetes . 1999,第1期

机译：巨噬细胞对T细胞受体转基因NOD小鼠中β细胞细胞毒性CD8 + T细胞的发育和激活的绝对要求
4. Changes in Cd4+ and Cd8+ T-Cell Subpopulations in Chickens Vaccinated with La Sota or V4 Strains of Ndv [C] . . 2005

机译：接种La Sota或Ndv V4株疫苗的鸡中Cd4 +和Cd8 + T细胞亚群的变化
5. Label-Free CD8+ T-Cell Purification and Electroporation in Relation to Car T-Cell Therapy [D] . Ringwelski, Beth Anne. 2020

机译：无标记的CD8 + T细胞纯化和电穿孔与汽车T细胞疗法有关
6. CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naïve T-cell anergy [O] . Aizhang Xu, Andrew Freywald, Yufeng Xie, 2017

机译：CD8 +记忆性T细胞膨胀可通过幼稚的T细胞无反应性削弱受损的CD4 + T细胞依赖性CD8 + T细胞免疫力
7. CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naiuml;ve T-cell anergy [O] . Aizhang Xu, Andrew Freywald, Yufeng Xie, 2017

机译：CD8 + 内存T细胞膨胀使得通过Naïvet细胞anergy损害CD4 + T细胞依赖性CD8 + T细胞免疫力

Septin9 is involved in T-cell development and CD8+ T-cell homeostasis

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